Reduced bone mass accrual in mouse model of repetitive mild traumatic brain injury

Journal of Rehabilitation Research and Development
Hongrun YuSubburaman Mohan

Abstract

Traumatic brain injury (TBI) can affect bone by influencing the production/actions of pituitary hormones and neuropeptides that play significant regulatory roles in bone metabolism. Previously, we demonstrated that experimental TBI exerted a negative effect on the skeleton. Since mild TBI (mTBI) accounts for the majority of TBI cases, this study was undertaken to evaluate TBI effects using a milder impact model in female mice. Repetitive mTBI caused microhemorrhaging, astrocytosis, and increased anti-inflammatory protective actions in the brain of the impacted versus control mice 2 wk after the first impact. Serum levels of growth regulating insulin-like growth factor 1 (IGF-I) were reduced by 28.9%. Bone mass was reduced significantly in total body as well as individual skeletons. Tibial total cortical density was reduced by 7.0%, which led to weaker bones, as shown by a 31.3% decrease in femoral size adjusted peak torque. A 27.5% decrease in tibial trabecular bone volume per total volume was accompanied by a 34.3% (p = 0.07) decrease in bone formation rate (BFR) per total area. Based on our data, we conclude that repetitive mTBI exerted significant negative effects on accrual of both cortical and trabecular bone mass in mice ...Continue Reading

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Citations

May 29, 2019·Journal of Neuroscience Research·Matthew I HiskensAndrew S Fenning
Dec 14, 2019·Scientific Reports·Chandrasekhar KesavanSubburaman Mohan
Mar 21, 2018·Frontiers in Neurology·Nikita M BajwaSubburaman Mohan
Jan 12, 2021·Frontiers in Psychology·Ryan R KellyAmanda C LaRue

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