Reduced brain content of arachidonic acid and docosahexaenoic acid is related to the severity of liver fibrosis.

Digestive Diseases and Sciences
Chih-Cheng ChenChun-Yu Yang

Abstract

Cognitive deficiency noted post-liver transplantation might be a result of consequential metabolic derangement before liver transplantation. Long-chain polyunsaturated fatty acids, especially arachidonic acid (AA) and docosahexaenoic acid (DHA), affect the development of the central nervous system and its absorption is influenced by obstructive jaundice. To investigate the possible relationship between the brain content of AA and DHA with the severity of obstructive jaundice using a bile duct ligation rat model. Sprague-Dawley rats were divided into three groups: Sham (n = 5): rats received sham operation on P17 (17 days after delivery) and were sacrificed on P31; BDL2w (n = 5): rats received bile duct ligation and were sacrificed on P31; BDL4w (n = 7): rats received bile duct ligation and were sacrificed on P45. Liver function test, histopathology, and fatty acid composition of the brain tissues were analyzed. The Sham group had significantly lowered total/direct bilirubin level (0.6 + 0.1/0.3 + 0.1 mg/dl) as compared to the BDL2w group (3.8 + 1.5/1.6 + 1.0 mg/dl) and the BDL4w group (4.3 + 0.6/3.3 + 0.5 mg/dl) (P = 0.04 and 0.008, respectively). Liver fibrosis and inflammatory changes of hepatocytes increased from the Sham gr...Continue Reading

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Citations

Dec 4, 2012·Digestive Diseases and Sciences·Chih-Cheng ChenLi-Tung Huang
Feb 24, 2016·International Immunopharmacology·Luxi Chen, Jianhua Yu
Apr 22, 2015·Chinese Medicine·Shao-Ru ChenYi-Tao Wang

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