Reduced capability of transmitting high frequency impulses in tail nerves of diabetic rats

Muscle & Nerve
J F NielsenV K Nielsen

Abstract

The effect of long-term (40 min) high frequency stimulation (143 Hz) of sensory-motor tail nerves was studied in normal and in streptozotocin-diabetic rats. The study comprised a 6-week period, repeating the test at 2-week intervals. In the initial (prediabetic) study, single experiments showed a mild depression of the peak-to-peak amplitude during high frequency stimulation, which reversed completely during a subsequent rest period. In normal rats, the amplitude depression was unchanged in repeated tests over a 6-week period. Diabetic rats showed a greater amplitude depression during high frequency stimulation. The difference was statistically significant after 2 weeks, but showed no further change at subsequent tests. The greater decrease in the amplitude in diabetic rats may reflect a depression of the axon membrane function, which may be the functional correlate to the inhibition of the Na/K ATPase activity in diabetes, described by others. Monitoring of the axon membrane functional capacity may have clinical implications in the control of peripheral neuropathies.

References

Nov 1, 1977·Journal of Neurology, Neurosurgery, and Psychiatry·F BehseF Carlsen
Apr 1, 1990·Muscle & Nerve·L R Robinson, V K Nielsen
May 1, 1987·Annals of Neurology·T BrismarD A Greene
Aug 1, 1973·Electroencephalography and Clinical Neurophysiology·T Miyoshi, I Goto
Sep 1, 1974·Journal of the Neurological Sciences·A K Sharma, P K Thomas
Jan 1, 1974·European Neurology·W TackmannH J Lehmann
Jul 1, 1972·Physiological Reviews·R C Thomas
Dec 1, 1973·The American Journal of Physiology·G M Schoepfle, C R Katholi
Jul 1, 1983·Metabolism: Clinical and Experimental·T Brismar
Apr 3, 1957·The Journal of Physiology·J M RITCHIE, R W STRAUB
Dec 1, 1964·The Journal of Clinical Investigation·S G ELIASSON

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Citations

Oct 1, 1994·Diabetes Research and Clinical Practice·P LindströmA A Sima
Sep 12, 2006·Experimental Neurology·Massimo LeandriGianluigi Lunardi
Apr 26, 2000·Journal of the Peripheral Nervous System : JPNS·H AndersenV K Nielsen
Jan 1, 1994·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·J E JensenO H Sørensen
Jan 24, 2015·Prosthetics and Orthotics International·Dennis Janisse, Erick Janisse

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