PMID: 8960400Sep 1, 1996Paper

Reduced capacity of cardiac efferent sympathetic neurons to release noradrenaline and modify cardiac function in tachycardia-induced canine heart failure

Canadian Journal of Physiology and Pharmacology
R CardinalJ A Armour

Abstract

To investigate the capacity of efferent sympathetic neurons to modulate the failing heart, stellate ganglion stimulation was performed in dogs with biventricular heart failure induced by rapid ventricular pacing (240 beats/min) for 4-6 weeks. Less noradrenaline was released from cardiac myoneural junctions into coronary sinus blood in response to left stellate ganglion stimulation in anesthetized failing heart preparations (582 pg/mL, lower and upper 95% confidence intervals of 288 and 1174 pg/mL, n = 19) compared with healthy heart preparations (6391 pg/mL, 95% confidence intervals of 4180 and 9770 pg/mL, n = 14; p < 0.001). There was substantial adrenaline extraction by failing hearts (49 +/- 6%), although it was slightly lower than in healthy heart preparations (65 +/- 9%, p = 0.055). In contrast with healthy heart preparations, no net release of adrenaline occurred during stellate ganglion stimulation in any of the failing heart preparations, and ventricular tissue levels of adrenaline fell below the sensitivity limit of the HPLC technique. In failing heart preparations, maximal electrical stimulation of right or left stellate ganglia resulted in minimal augmentation of left ventricular intramyocardial (17%) and chamber (12...Continue Reading

References

Sep 15, 1988·The Biochemical Journal·J EscribanoF Garcia-Carmona
Aug 1, 1972·Circulation Research·P GauthierJ De Champlain
Dec 1, 1964·The Journal of Clinical Investigation·C A CHIDSEYE BRAUNWALD

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Citations

Jul 24, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J Andrew Armour
Jun 15, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Gerald H HankesLouis J Dell'Italia

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