PMID: 7517598Jul 1, 1994Paper

Reduced cavitation-induced cellular damage by the antioxidative effect of vitamin E

Ultrasonics
D SuhrD F Hülser

Abstract

Fragmentation of human urinary and biliary stones by shock waves in extracorporeal lithotripsy is accompanied by tissue damage. Both the fragmentation as well as the side effects are often attributed to cavitation. The hazardous potential of cavitation is not only of a physical nature but also of a chemical nature, because of the generation of free radicals, e.g. .OH, .H and .O2. After the application of shock waves, we have demonstrated cavitation-generated free radicals in cell-free solutions and also in the surviving and intact suspended MGH-U1 cells by hydroethidine measurements. Under electron microscopical inspection, the same cells exhibited perinuclear cisternae, damaged mitochondria and numerous intracellular vacuoles. The contribution of free radicals to cell damage was investigated by reducing the vitamin E level in rats by a tocopherol free diet and by incubating L1210 cells in a tocopherol enriched medium. After 250 shock waves, ex vivo erythrocytes revealed a 75% increase in total cell disruption over cells from non-depleted rats. The in vitro experiments with L1210 cells exhibited a moderate protection by the addition of this scavenger of free radicals.

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Citations

May 11, 2000·Lasers in Surgery and Medicine·A SondénB T Kjellström
Jun 1, 1996·Ultrasonics·D SuhrD F Hülser
Jan 1, 1996·Ultrasound in Medicine & Biology·D SuhrD F Hülser
Dec 31, 2003·Journal of the American College of Surgeons·Vijay Maker, John Layke
Feb 27, 2003·Ultrasound in Medicine & Biology·Morton W MillerLinda F Battaglia
Jan 1, 1996·Ultrasound in Medicine & Biology·M W MillerA A Brayman
Dec 5, 1998·Ultrasound in Medicine & Biology
Jul 13, 1999·Free Radical Biology & Medicine·G ValenB T Kjellström
Mar 20, 2004·Ultrasonics Sonochemistry·Tinghe YuTimothy J Mason
Oct 2, 2002·Lasers in Surgery and Medicine·Anders SondénB Thomas Kjellström
Jun 9, 2004·Ultrasound in Medicine & Biology·Hidemi HondaHiroshi Kitagawa
Aug 28, 2012·The Journal of Chemical Physics·Stacey L Meadley, Fernando A Escobedo

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