Reduced CD8+ T cells infiltration can be associated to a malignant transformation in potentially malignant oral epithelial lesions

Clinical Oral Investigations
Aline Lauda Freitas ChavesRosy Iara Maciel de Azambuja Ribeiro

Abstract

The aim of this study was to evaluate the immunohistochemical expressions of PD1, CD4+, and CD8+ in premalignant lesions (OPML) that were transformed into oral squamous cell carcinoma OSCC (OPML-OSCC), in OSCC and also in premalignant lesions that were not transformed into OSCC (OPML-NOSSC). Retrospective analyses were performed in order to verify the demographic characteristics of the patients. CD4, CD8, and PD1 IMH studies were carried out on OPML and OSCC samples from 11 patients with OPML-OSCC and OPML, together with samples from 14 patients with OPML-NOSCC. The differences between OPML-OSCC and OPML-NOSCC were analyzed. Non-homogenous leukoplakia, together with the related oral subsite, and the lack of an exposure to tobacco, were all associated with malignant transformations. There were no statistical differences in the PD1 expression and the CD4+ cells in OPML-OSCC and OPML-NOSCC. A significant increment in the CD8+ cells was noted in the OPML that evolved into carcinomas when compared with OPML-NOSCC (p = 0.05), whereas there were higher CD8+ cells levels in the carcinomas when compared with the OPML that evolved into carcinomas (p = 0.027). CD8+ cells infiltrate more in OPML-NOSCC than in OPML-OSCC. Carcinoma is more i...Continue Reading

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Citations

Sep 24, 2020·International Journal of Molecular Sciences·Roberto GrigolatoLorenzo Lo Muzio
Jan 16, 2019·International Journal of Environmental Research and Public Health·Dorina LauritanoFrancesco Carinci
Aug 28, 2019·Clinical and Experimental Dental Research·Toshio YoshidaHiroki Bukawa
Feb 28, 2021·Archivum Immunologiae Et Therapiae Experimentalis·Mahsa Keshavarz-Fathi, Nima Rezaei
Jan 5, 2021·Current Opinion in Otolaryngology & Head and Neck Surgery·Crisitna GurizzanPaolo Bossi
Feb 16, 2021·Applied Immunohistochemistry & Molecular Morphology : AIMM·Andressa F P MiguelElena R C Rivero

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