Reduced CDHR3 expression in children wheezing with rhinovirus.

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
Katarina Stenberg-HammarCilla Söderhäll

Abstract

Rhinovirus-induced wheezing in young children has been associated with increased asthma risk at school age. Recently, the transmembrane protein cadherin-related family member 3 (CDHR3) was identified as the RV-C receptor and the genetic variant rs6967330 (p.Cys529Tyr) was reported to be associated with enhanced RV-C binding and increased replication in vitro. The aim of this study was to examine rs6967330 genotypes and mRNA expression of CDHR3 in relation to presence of rhinovirus and clinical symptoms in children with acute wheezing and compare to a group of age-matched healthy children. rs6967330;G>A was genotyped (n = 216), and CDHR3 mRNA expression was measured in peripheral blood leukocytes (n = 69) from a subgroup of children wheezing with RV infection acute and at a follow-up visit 2-3 months later, and in healthy controls. Standardized TaqMan assays were used. The risk allele rs6967330-A was over-represented in the wheezing group (P < .001). Reduced mRNA levels of CDHR3 were found in children with acute wheezing as compared to the control group (P = .001). Children with the rs6967330 genotypes AA/AG showed the largest differences in CDHR3 expression between acute and follow-up visit (P < .04). Preschool children with RV...Continue Reading

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Citations

Oct 20, 2018·Current Opinion in Pulmonary Medicine·Esther Herrera-LuisMaria Pino-Yanes
Mar 28, 2019·American Journal of Respiratory Cell and Molecular Biology·Sarmila BasnetJames E Gern
Feb 6, 2020·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Philippe Eigenmann
Jun 15, 2019·Viruses·Silvia VandiniMarcello Lanari
Feb 16, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Philippe Eigenmann
Apr 2, 2019·The Journal of Allergy and Clinical Immunology·Jamie L EvermanMax A Seibold

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