PMID: 11607121Dec 1, 1990Paper

Reduced coenzyme F420: heterodisulfide oxidoreductase, a proton- translocating redox system in methanogenic bacteria

Proceedings of the National Academy of Sciences of the United States of America
U DeppenmeierG Gottschalk

Abstract

Washed everted vesicles of the methanogenic bacterium strain Go1 were found to couple the F420H2-dependent heterodisulfide reduction with the transfer of protons across the membrane into the lumen of the everted vesicles. The transmembrane electrochemical potential of protons thereby generated was shown to be competent in driving ATP synthesis from ADP + Pi, exhibiting a stoichiometry of 2 H+ translocated or 0.4 ATP synthesized per F420H2 oxidized. This enzyme system exhibits the phenomenon of coupling and uncoupling and represents a different kind of electron transport chain with the heterodisulfide of 2-mercaptoethanesulfonate and 7-mercaptoheptanoylthreonine phosphate as terminal electron acceptor. The heterodisulfide and methane are formed in the methyl coenzyme M reductase reaction. The reducing equivalents are derived from reduced coenzyme F420, which represents an analogue of NADH + H+ in other respiratory chains. It is assumed that the proton-translocating oxidoreductase discovered in strain Go1 is of principal importance to all methanogenic bacteria not utilizing H2.

References

Aug 15, 1989·Biochemical and Biophysical Research Communications·K InatomiM Futai
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J N ReeveC T Walsh
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K M NollR S Wolfe
Sep 1, 1983·European Journal of Biochemistry·W Kühn, G Gottschalk
Jun 1, 1983·Archives of Microbiology·P van der MeijdenG D Vogels

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Citations

Sep 1, 1996·Environmental Monitoring and Assessment·J T Keltjens, G D Vogels
Dec 1, 1992·Journal of Bioenergetics and Biomembranes·M BlautG Gottschalk
Apr 2, 2008·Archives of Microbiology·Regina Spanheimer, Volker Müller
Apr 17, 2008·Archives of Microbiology·Katrin WeidenbachRuth A Schmitz
Apr 13, 2005·Molecular Genetics and Genomics : MGG·Claudia EhlersRuth A Schmitz
Apr 21, 2006·Molecular Genetics and Genomics : MGG·Katharina VeitRuth A Schmitz
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Gargi KulkarniWilliam W Metcalf
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·F D SauerJ K Kramer
Feb 1, 1992·European Journal of Biochemistry·P HaaseG Gottschalk
Feb 15, 1997·European Journal of Biochemistry·A KünkelR Hedderich
Apr 5, 2005·Archaea : an International Microbiological Journal·Claudia EhlersRuth A Schmitz
Apr 29, 2006·Journal of Molecular Microbiology and Biotechnology·G FritzP M H Kroneck
Jan 7, 2011·PloS One·Ghader BashiriEdward N Baker
Jan 1, 1994·Antonie van Leeuwenhoek·M Blaut
Dec 1, 1991·Current Opinion in Genetics & Development·W Zillig
Jul 16, 2010·The FEBS Journal·Cornelia WelteUwe Deppenmeier
Aug 13, 2014·The FEBS Journal·Addison C McCarver, Daniel J Lessner
Apr 4, 1995·Biochimica Et Biophysica Acta·M Lübben
Dec 18, 2013·Biochimica Et Biophysica Acta·Cornelia Welte, Uwe Deppenmeier
Jan 16, 1997·Biochimica Et Biophysica Acta·P Dimroth
Mar 23, 2017·Microbes and Environments·Shawn E McGlynn
Jan 1, 1992·Critical Reviews in Biochemistry and Molecular Biology·J G Ferry
Jun 21, 2018·Annual Review of Microbiology·Volker MüllerMirko Basen
Sep 8, 2017·Journal of Virology·Katrin WeidenbachRuth A Schmitz
Apr 29, 2016·Microbiology and Molecular Biology Reviews : MMBR·Chris GreeningColin J Jackson
Sep 20, 2019·Microbiology and Molecular Biology Reviews : MMBR·Thomas D Mand, William W Metcalf
Dec 23, 2017·Molecular Microbiology·Anne BuddewegRuth A Schmitz

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