Reduced Condensing and Ordering Effects by 7-Ketocholesterol and 5β,6β-Epoxycholesterol on DPPC Monolayers

Langmuir : the ACS Journal of Surfaces and Colloids
Dana-Marie TelesfordHeather C Allen

Abstract

The exposure of organic-coated marine aerosols containing cholesterol (Chol) to radiation and/or an oxidizing atmosphere results in the formation of oxidized derivatives or oxysterols and will likely change aerosol surface properties. However, the intermolecular interactions between oxysterols and other lipid components and their influence on the surface properties of marine aerosols are not well-known. To address this question, the interfacial behavior and domain morphology of model Langmuir monolayers of two ring-substituted oxysterols, 7-ketocholesterol (7-KChol) and 5β,6β-epoxycholesterol (5,6β-EChol), mixed with 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) were investigated by means of compression isotherms and Brewster angle microscopy (BAM) over a broad range of surface pressures and sterol molar ratios. Mixed DPPC/cholesterol (Chol) monolayers were also measured for comparison. The results of compression experiments showed that the condensing effect induced on mixed DPPC/sterol monolayers at low surface pressures and for intermediate molar ratios (0.3 ≤ X(sterol) ≤ 0.7) was weaker for oxysterols than for Chol. Additionally, mixed DPPC/oxysterol monolayers exhibited markedly smaller (∼2-3-fold) interfacial rigidity...Continue Reading

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Citations

Mar 10, 2016·Chemistry and Physics of Lipids·Waldemar KuligIlpo Vattulainen
Jun 21, 2016·Journal of Colloid and Interface Science·Ellen M AdamsHeather C Allen
Nov 18, 2016·Physical Chemistry Chemical Physics : PCCP·Ellen M AdamsHeather C Allen
Sep 17, 2019·Chemistry and Physics of Lipids·J L Fidalgo RodriguezP Dynarowicz-Latka
Sep 26, 2019·ACS Omega·Luis Real Hernandez, Rafael Jimenez-Flores

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