Reduced Corneal Endothelial Cell Density in Patients With Dry Eye Disease

American Journal of Ophthalmology
Ahmad KheirkhahReza Dana

Abstract

To evaluate corneal endothelial cell density (ECD) in patients with dry eye disease (DED) compared to an age-matched control group. Cross-sectional, controlled study. This study included 90 eyes of 45 patients with moderate to severe DED (aged 53.7 ± 9.8 years) and 30 eyes of 15 normal controls (aged 50.7 ± 9.8 years). All subjects had a complete ophthalmic evaluation including symptom assessment using the Ocular Surface Disease Index (OSDI) and corneal fluorescein staining. In addition, laser scanning in vivo confocal microscopy was performed to measure the density of the following parameters in the central cornea: endothelial cells, subbasal nerves, and subbasal immune dendritic cells. Corneal ECD was significantly lower in the DED group (2595.8 ± 356.1 cells/mm(2)) than in the control group (2812.7 ± 395.2 cells/mm(2), P = .046). The DED group showed significantly lower corneal subbasal nerve density (17.1 ± 6.9 mm/mm(2)) compared to the control group (24.7 ± 4.4 mm/mm(2), P < .001). Dendritic cell density was significantly higher in the DED group than in the controls (111.7 ± 137.3 vs 32.0 ± 24.4 cells/mm(2), respectively, P = .002). There were statistically significant correlations between corneal ECD and dry eye severity ...Continue Reading

References

Dec 1, 1978·The British Journal of Ophthalmology·R M NagyL M McGreevy
Jan 1, 1990·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·H RixenJ Friedrich
Nov 1, 1987·Australian and New Zealand Journal of Ophthalmology·A M BrooksW E Gillies
Sep 1, 1984·Archives of Ophthalmology·N IshidaJ V Aquavella
Jun 1, 1996·Archives of Ophthalmology·J S Saini, S Mittal
Jun 17, 1998·Ophthalmology·C A McCartyH R Taylor
Apr 17, 2003·Experimental Eye Research·Linda J MüllerTimo M T Tervo
Jul 1, 1954·A.M.A. Archives of Ophthalmology·S SIGELMAN, J S FRIEDENWALD
Nov 25, 2003·Eye·S BoniniA Lambiase
Aug 25, 2004·Investigative Ophthalmology & Visual Science·José M Benítez del CastilloJulian Garcia-Sanchez
Jul 29, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Béla ErdélyiJános Németh
Jan 2, 2007·Investigative Ophthalmology & Visual Science·José M Benítez-Del-CastilloJulian García-Sánchez
Dec 17, 2008·Current Eye Research·Tatsuya MimuraYutaka Awaya
Jul 25, 2009·Investigative Ophthalmology & Visual Science·Hui LinZuguo Liu
Dec 29, 2009·Experimental Eye Research·Carl F MarfurtLauren Dvorscak
Jan 13, 2010·Archives of Ophthalmology·Kimberly L MillerStephen C Pflugfelder
Jan 8, 2011·Investigative Ophthalmology & Visual Science·Xiaodong ZhengYuichi Ohashi
Feb 12, 2011·American Journal of Ophthalmology·Mouhamed Al-AqabaHarminder S Dua
Mar 20, 2012·Progress in Retinal and Eye Research·Stefano BarabinoReza Dana
Nov 21, 2012·Seminars in Ophthalmology·Albert AlhatemPedram Hamrah
May 15, 2013·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Edoardo VillaniRoberto Ratiglia
Jul 25, 2013·Investigative Ophthalmology & Visual Science·Gulfidan BitirgenRefik Oltulu
Aug 10, 2013·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Michael J Doughty
Oct 16, 2013·Journal of Diabetes Science and Technology·Mitra TavakoliRayaz A Malik
Oct 26, 2013·JAMA Ophthalmology·Alessandro LambiaseStefano Bonini

❮ Previous
Next ❯

Citations

Sep 23, 2016·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Gabriela MahelkovaDagmar Dotrelova
Nov 15, 2016·The Ocular Surface·Francesco SabatinoStefano Bonini
Jul 1, 2017·International Journal of Molecular Sciences·Xiaobo ZhangWei Li
Jul 26, 2017·Acta Ophthalmologica·Joanna KokotEdward Wylęgała
Oct 7, 2017·The British Journal of Ophthalmology·Tommy C Y ChanVishal Jhanji
Nov 28, 2018·Investigative Ophthalmology & Visual Science·Takefumi Yamaguchi
Nov 28, 2018·Investigative Ophthalmology & Visual Science·Yukihiro Matsumoto, Osama M A Ibrahim
Apr 30, 2020·BMC Ophthalmology·Napaporn Tananuvat, Natawan Khumchoo
Dec 8, 2019·Journal of Clinical Medicine·Amaya Pérez Del PalomarTanima Bose
Oct 17, 2020·The Ocular Surface·Hossein AghaeiMohammad Mirzakhan Kordamiri
May 1, 2021·Journal of Clinical Medicine·Lina MikalauskieneReda Zemaitiene
Apr 22, 2021·Survey of Ophthalmology·Robert O BarattaDavid J Calkins
Jun 9, 2021·American Journal of Ophthalmology·Min ZhouPengxia Wan
Jul 13, 2021·PloS One·Vannarut SatitpitakulThanachaporn Kittipibul
Sep 21, 2021·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Jelena Marie KezicMariapia Degli-Esposti
Oct 17, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yi-Jen HsuehHung-Chi Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Optometry and Vision Science : Official Publication of the American Academy of Optometry
Edoardo VillaniPaolo Nucci
Ocular Immunology and Inflammation
Fatih OzcuraMehmet Rami Helvaci
© 2021 Meta ULC. All rights reserved