Reduced cortical bone density with normal trabecular bone density in girls with Turner syndrome.

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
C R HolroydE M Dennison

Abstract

This study of 22 girls with Turner syndrome (TS) demonstrates a reduction in bone mineral apparent density (BMAD) at the femoral neck along with a reduction in cortical bone density at the radius (with sparing of trabecular bone). These findings may account for the increased fracture risk noted in this population. Increased fracture risk is a feature of TS; however, the reasons for this are unclear. Little is known regarding cortical and trabecular bone mineral density (BMD) in TS. We have addressed this by measurement of volumetric bone mineral density (vBMD) using peripheral quantitative computed tomography (pQCT). We studied 22 females with TS and 21 females without TS; mean ages 12.7 and 12.9 years, respectively. Bone mass measurements were made by dual-energy X-ray absorptiometry (DXA) of the lumbar spine and femur and pQCT of the radius. BMAD was calculated from DXA values. We utilized published reference data to generate Z-scores for both populations. The mean BMAD Z-score at the lumbar spine was not significantly different in individuals with TS compared to the controls. At the femoral neck, individuals with TS had a significantly lower BMAD Z-score compared to the controls (-1.32 vs. -0.14, p = 0.001). At the distal ra...Continue Reading

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Citations

May 6, 2014·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Judith E AdamsUNKNOWN International Society of Clinical Densitometry
Mar 25, 2014·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Maria Luisa BianchiLeanne Ward
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Mar 31, 2021·Seminars in Reproductive Medicine·Navira SamadFrances Milat
Sep 4, 2021·Endocrine Reviews·Peter R EbelingFrances Milat

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