Reduced cortical thickness in first episode schizophrenia

Schizophrenia Research
C Christoph SchultzRalf G M Schlösser

Abstract

Previous morphometric studies are suggesting altered cortical thickness mainly in prefronto-temporal regions in first episode schizophrenia. In an extension of these earlier studies, we used an entire cortex vertex-wise approach and an automated clustering for the detection and exact quantification of cortical thickness alterations in first episode schizophrenia. A group of 54 patients with first episode schizophrenia according to DSM-IV and 54 age and gender matched healthy control subjects were included. All participants underwent high-resolution T1-weighted MRI scans on a 1.5 T scanner. Cortical thickness was estimated as the distance between the gray-white matter border and the pial surface using an automated computerized algorithm (Freesurfer Software). Statistical cortical maps were created to estimate differences of cortical thickness between groups based on this entire cortex analysis. Significant cortical thinning was observed in first episode schizophrenia patients relative to controls in a number of cortical areas including the dorsolateral and frontopolar cortices, the anterior cingulate cortex, a ventrolateral-orbitofrontal cluster, as well as the superior temporal cortices and superior parietal lobe. Cortical thin...Continue Reading

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Citations

Mar 7, 2013·Schizophrenia Bulletin·Akihiko SasamotoToshiya Murai
May 11, 2013·Brain Topography·Dusan HirjakPhilipp Arthur Thomann
Oct 1, 2013·Schizophrenia Bulletin·Carl Christoph SchultzHeinrich Sauer
Dec 31, 2014·Schizophrenia Research and Treatment·Ravi Philip Rajkumar
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Mar 26, 2011·Schizophrenia Bulletin·Stefan EhrlichScott R Sponheim
Apr 22, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·C Christoph SchultzRalf G M Schlösser
May 23, 2012·PloS One·Li KongPhilipp Arthur Thomann
Sep 11, 2013·Journal of Psychiatry & Neuroscience : JPN·Clifford CassidyRidha Joober
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Oct 16, 2016·Brain Imaging and Behavior·Dusan HirjakPhilipp A Thomann
Mar 5, 2017·Progress in Neuro-psychopharmacology & Biological Psychiatry·Dusan HirjakRobert C Wolf

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