Reduced density of glutamine synthetase immunoreactive astrocytes in different cortical areas in major depression but not in bipolar I disorder

Frontiers in Cellular Neuroscience
Hans-Gert BernsteinBernhard Bogerts

Abstract

There is increasing evidence for disturbances within the glutamate system in patients with affective disorders, which involve disruptions of the glutamate-glutamine-cycle. The mainly astroglia-located enzyme glutamine synthetase (GS) catalyzes the ATP-dependent condensation of ammonia and glutamate to form glutamine, thus playing a central role in glutamate and glutamine homoeostasis. However, GS is also expressed in numerous oligodendrocytes (OLs), another class of glial cells implicated in mood disorder pathology. To learn more about the role of glia-associated GS in mental illnesses, we decided to find out if numerical densities of glial cells immunostained for the enzyme protein differ between subjects with major depressive disorder, bipolar disorder (BD), and psychically healthy control cases. Counting of GS expressing astrocytes (ACs) and OLs in eight cortical and two subcortical brain regions of subjects with mood disorder (N = 14), BD (N = 15), and controls (N = 16) revealed that in major depression the densities of ACs were significantly reduced in some cortical but not subcortical gray matter areas, whereas no changes were found for OLs. In BD no alterations of GS-immunoreactive glia were found. From our findings we c...Continue Reading

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Citations

Aug 27, 2016·European Archives of Psychiatry and Clinical Neuroscience·Liliana Ramona DemenescuMartin Walter
Oct 21, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Meng LiMartin Walter
Mar 21, 2017·Glia·Qian WangTian-Ming Gao
Aug 22, 2018·Molecular Psychiatry·Paul J HarrisonCharlotte H Harrison
Aug 6, 2019·Frontiers in Psychiatry·Luca SteardoPasquale De Fazio
Mar 2, 2017·World Journal of Gastroenterology : WJG·Sanne van ErpAndrea van der Meulen-de Jong
Mar 15, 2018·Frontiers in Molecular Neuroscience·Boldizsár Czéh, Szilvia A Nagy
Jul 20, 2019·Reviews in the Neurosciences·Hans-Gert BernsteinJohann Steiner
Feb 23, 2021·Frontiers in Psychiatry·Liam Anuj O'LearyNaguib Mechawar
Jul 18, 2017·Neuroscience and Biobehavioral Reviews·Mehdi GhasemiAhmad Salehi

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