Reduced diffusion in a subset of acute MS lesions: a serial multiparametric MRI study.

AJNR. American Journal of Neuroradiology
P EiseleA Gass

Abstract

MRI studies have focused on newly developing MS lesions to characterize the early pathology of the disease. DWI is highly sensitive to acute and chronic tissue changes in MS. We characterized the development of acute MS lesions by using DWI in a multiparametric MRI protocol. Seventy-two consecutive patients presenting with a new symptom with definite MS or a CIS suggestive of central nervous system demyelination were screened with MRI. Patients who showed an acute MRI lesion with a reduction of ADC were studied with serial MRI for up to 4 months after presentation. Ten of 72 screened patients who showed a lesion with a reduced ADC were each examined 4-7 times, resulting in 52 examinations in total. We identified a characteristic sequence of signal-intensity changes: 1) days 0-7: slight T2 hyperintensity and prominent ADC reduction (maximum, -66%), faint or no enhancement on postcontrast T1-weighted images; 2) days 7-10: prominent T2 hyperintensity and contrast enhancement, ADC normalization/pseudonormalization; 3) up to 4 weeks: elevated ADC values, prominent enhancement on postcontrast images; 4) after 4 weeks: partial reversibility of T2 hyperintensity, ADC elevation, and resolution of contrast enhancement. In a subgroup of p...Continue Reading

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Citations

Dec 29, 2013·AJR. American Journal of Roentgenology·Fernanda C Rueda-LopesEmerson L Gasparetto
Jan 27, 2016·Journal of the Neurological Sciences·P PreziosaG Comi
Oct 17, 2015·AJNR. American Journal of Neuroradiology·I BlystadE-M Larsson
Oct 21, 2015·Multiple Sclerosis International·Justin M HonceEric Nyberg
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Sep 25, 2015·Neurology. Neuroimmunology and Neuroinflammation·Martina AbsintaDaniel S Reich
Apr 30, 2016·Nature Reviews. Neurology·Martina AbsintaDaniel S Reich
Aug 18, 2016·Journal of Neurology, Neurosurgery, and Psychiatry·Martijn T WijburgMike P Wattjes
Dec 11, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Philipp EiseleAchim Gass
Nov 14, 2015·Multiple Sclerosis : Clinical and Laboratory Research·Mike P WattjesJoep Killestein
Sep 14, 2013·The Neuroradiology Journal·A CatalucciM Gallucci
Oct 11, 2015·Multiple Sclerosis : Clinical and Laboratory Research·Philipp EiseleAchim Gass
Sep 3, 2013·Therapeutic Advances in Neurological Disorders·Alex RoviraJuli Alonso
Mar 16, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Piotr SowaMona K Beyer
Apr 6, 2018·Neurology. Clinical Practice·Philipp EiseleAchim Gass
Sep 30, 2016·Iranian Journal of Radiology : a Quarterly Journal Published by the Iranian Radiological Society·Yasmin DavoudiAli Shoeibi
Nov 20, 2016·Journal of Magnetic Resonance Imaging : JMRI·Hailin WanGuohong Tian
Mar 10, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Marine Boudot de la MotteElisabeth Maillart
Apr 30, 2017·The Neuroradiology Journal·Amin Abolhasani ForoughiAli Khorsand
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Oct 2, 2021·Neuroradiology·Siddhartha GaddamanuguAparna Singhal

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