Reduced dose measurement of absolute myocardial blood flow using dynamic SPECT imaging in a porcine model

Medical Physics
Rachel TimminsR Glenn Wells

Abstract

Absolute myocardial blood flow (MBF) and myocardial flow reserve (MFR) measurements provide important additional information over traditional relative perfusion imaging. Recent advances in camera technology have made this possible with single-photon emission tomography (SPECT). Low dose protocols are desirable to reduce the patient radiation risk; however, increased noise may reduce the accuracy of MBF measurements. The authors studied the effect of reducing dose on the accuracy of dynamic SPECT MBF measurements. Nineteen 30-40 kg pigs were injected with 370 + 1110 MBq of Tc-99m sestamibi or tetrofosmin or 37 + 111 MBq of Tl-201 at rest + stress. Microspheres were injected simultaneously to measure MBF. The pigs were imaged in list-mode for 11 min starting at the time of injection using a Discovery NM 530c camera (GE Healthcare). Each list file was modified so that 3/4, 1/2, 1/4, 1/8, 1/16, and 1/32 of the original counts were included in the projections. Modified projections were reconstructed with CT-based attenuation correction and an energy window-based scatter correction and analyzed with FlowQuant kinetic modeling software using a 1-compartment model. A modified Renkin-Crone extraction function was used to convert the tra...Continue Reading

References

Mar 1, 1994·Circulation·M C GersonR C Elder
Oct 11, 2001·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·G T GullbergA J Sinusas
Jun 9, 2007·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Robert A deKempRob S B Beanlands
Jul 10, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Mireille LortieRobert A DeKemp
Aug 7, 2007·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Daniel S BermanGuido Germano
Jan 19, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Hidehiro IidaHiroshi Watabe
Apr 10, 2009·JACC. Cardiovascular Imaging·Daniel S BermanJohn D Friedman
Jun 16, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Paolo G Camici, Ornella E Rimoldi
Jul 4, 2009·Journal of the American College of Cardiology·Bernhard A HerzogPhilipp A Kaufmann
Dec 17, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Bernhard A HerzogPhilipp A Kaufmann
Jun 17, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Thomas A HollyUNKNOWN American Society of Nuclear Cardiology
Jun 30, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Moshe BocherLana Volokh
Jul 3, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ran KleinRobert A deKemp
Sep 23, 2010·Physics in Medicine and Biology·Grant T GullbergThomas F Budinger
Nov 19, 2010·Radiology·James A Brink, E Stephen Amis
Feb 15, 2011·Physics in Medicine and Biology·Krzysztof KacperskiBrian F Hutton
Jun 1, 2011·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Stefania DanieleAlberto Cuocolo
Jul 13, 2011·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·J Wells AskewMichael K O'Connor
Feb 14, 2012·Current Cardiology Reports·Piotr J SlomkaGuido Germano
Mar 15, 2012·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Maria C ZiadiRob S B Beanlands
Jun 27, 2012·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Antti SarasteJuhani Knuuti
Jan 17, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ryo NakazatoPiotr J Slomka
Apr 13, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Simona Ben-HaimMarcelo F Di Carli
Sep 6, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·R Glenn WellsTerrence D Ruddy
Oct 5, 2014·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ran KleinBailing Hsu
Oct 15, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Ernest V Garcia

❮ Previous
Next ❯

Citations

Jun 25, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Lei WangYi-Da Tang
Feb 7, 2019·Physics in Medicine and Biology·Jing Wu, Chi Liu
Aug 5, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Maria SciammarellaElias H Botvinick
Jun 15, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·R Glenn WellsTerrence D Ruddy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
R Glenn WellsTerrence D Ruddy
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Hossam M SherifM Schwaiger
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
R Glenn WellsTerrence D Ruddy
Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
H SugiharaY Taniguchi
© 2021 Meta ULC. All rights reserved