Abstract
Vascular peripheral resistance is increased during hypertension, and endothelium-derived hyperpolarizing factor (EDHF) is an important for regulating vasodilation in small arteries. Therefore we characterized the role of EDHF in regulating vascular resistance of ocular ciliary arteries from spontaneous hypertensive rats (SHR) and age-matched Wistar Kyoto rats (WKY). Isometric tension recordings were used in isolated ocular ciliary artery segments from SHR and WKY. Ocular ciliary arteries pre-contracted with 100 microM norepinephrine exhibited a concentration-dependent relaxation to acetylcholine, and the effect on SHR arteries was smaller than that on WKY arteries (P < 0.05). The EDHF-mediated component of this relaxation, determined in the presence of 100 microM l-NAME plus 10 microM indomethacin, was also smaller in SHR than in WKY arteries (P < 0.05). Apamin (1 microM), a blocker of small-conductance calcium-activated K(+) (K(Ca)) channels, had no effect on EDHF-mediated relaxation in either preparation. However, charybdotoxin (0.1 microM), which blocks intermediate- and large-conductance K(Ca) channels, and iberiotoxin (0.1 microM), which blocks large-conductance K(Ca) channels, almost completely suppressed EDHF-mediated re...Continue Reading
References
Feb 1, 1978·The Journal of Physiology·W HalpernD M Warshaw
Jul 1, 1977·Circulation Research·M J Mulvany, W Halpern
Apr 15, 1976·Nature·M J Mulvany, W Halpern
Dec 1, 1990·Hypertension·D GebremedhinR J Roman
Aug 1, 1985·Circulation Research·D R HarderJ Lombard
Apr 1, 1994·Hypertension·S WolfM Reim
Mar 1, 1996·Circulation Research·W B CampbellD R Harder
Oct 23, 1997·Circulation·H HayakawaL Raij
Dec 30, 1998·Retina·R D SteigerwaltL Incandela
Mar 12, 1999·Journal of Molecular and Cellular Cardiology·C M Boulanger
Oct 12, 1999·British Journal of Pharmacology·G J WaldronC R Triggle
Dec 10, 1999·British Journal of Pharmacology·G EdwardsA H Weston
Mar 22, 2000·British Journal of Pharmacology·J F QuignardP M Vanhoutte
Aug 16, 2000·Proceedings of the National Academy of Sciences of the United States of America·R P BrandesR Busse
Feb 22, 2002·Current Opinion in Nephrology and Hypertension·William B Campbell, Kathryn M Gauthier
Feb 9, 2005·Hypertension·Kathryn M GauthierWilliam B Campbell
May 17, 2005·British Journal of Pharmacology·Arthur H WestonGillian Edwards
Jun 7, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yoshitomo MoriTadaaki Iwasaki
Oct 10, 2006·European Journal of Pharmacology·Malarvannan PannirselvamChris R Triggle
Dec 21, 2006·Japanese Journal of Ophthalmology·Yaru DongTakeshi Yoshitomi
Apr 27, 2007·Experimental Eye Research·Yaru DongTakeshi Yoshitomi
Jul 8, 2008·Experimental Eye Research·Yaru DongTakeshi Yoshitomi
Mar 4, 2009·Investigative Ophthalmology & Visual Science·Thomas DalsgaardUlf Simonsen
Citations
Mar 11, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Harald M StaussMichael G Anderson
Jan 14, 2016·Japanese Journal of Ophthalmology·Yaru DongTakeshi Yoshitomi
Jan 25, 2018·International Journal of Molecular Sciences·Kenichi GotoTakanari Kitazono
Nov 29, 2017·Bulletin of Experimental Biology and Medicine·D V Unt, G I Lobov
Nov 9, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Jun HanGuo-Wei He
Jun 28, 2017·Japanese Journal of Ophthalmology·Yusuke OhtaTakeshi Yoshitomi