Reduced efficacy of macrocyclic lactone treatments in controlling gastrointestinal nematode infections of weaner dairy calves in subtropical eastern Australia

Veterinary Parasitology
M Lyndal-MurphyP M Pepper

Abstract

Faecal Egg Count Reduction Tests (FECRTs) for macrocyclic lactone (ML) and levamisole (LEV) drenches were conducted on two dairy farms in the subtropical, summer rainfall region of eastern Australia to determine if anthelmintic failure contributed to severe gastrointestinal nematode infections observed in weaner calves. Subtropical Cooperia spp. were the dominant nematodes on both farms although significant numbers of Haemonchus placei were also present on Farm 2. On Farm 1, moxidectin pour-on (MXD) drenched at 0.5mg kg(-1) liveweight (LW) reduced the overall Cooperia burden by 82% (95% confidence limits, 37-95%) at day 7 post-drench. As worm burdens increased rapidly in younger animals in the control group (n=4), levamisole was used as a salvage drench and these calves withdrawn from the trial on animal welfare grounds after sample collection at day 7. Levamisole (LEV) dosed at 6.8mg kg(-1)LW reduced the worm burden in these calves by 100%, 7 days after drenching. On Farm 2, MXD given at 0.5mg kg(-1)LW reduced the faecal worm egg count of cooperioids at day 8 by 96% (71-99%), ivermectin oral (IVM) at 0.2mg kg(-1)LW by 1.6% (-224 to 70%) and LEV oral at 7.1mg kg(-1)LW by 100%. For H. placei the reductions were 98% (85-99.7%) fo...Continue Reading

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Citations

Feb 6, 2016·New Zealand Veterinary Journal·Amb OliverD M Leathwick
Jul 20, 2012·Parasitology International·Ana Carolina S ChagasWaldomiro Barioni Júnior
Nov 26, 2010·Australian Veterinary Journal·D K Rendell
Mar 25, 2014·Research in Veterinary Science·Claudio Alessandro M SakamotoAlvimar José da Costa
Feb 22, 2014·International Journal for Parasitology·Paul R TorgersonReinhard Furrer
Dec 10, 2013·Veterinary Parasitology·M Lyndal-MurphyP M Pepper
Dec 30, 2014·Veterinary Parasitology·J L CotterR B Besier
May 6, 2015·International Journal for Parasitology. Drugs and Drug Resistance·Dave M LeathwickTania S Waghorn
Dec 24, 2017·Tropical Animal Health and Production·V H SuarezA E Viñabal
Jul 30, 2014·The Journal of Veterinary Medical Science·Noboru KudoTakashi Oyamada

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