Reduced electron exposure for energy-dispersive spectroscopy using dynamic sampling

Ultramicroscopy
Yan ZhangCharudatta Phatak

Abstract

Analytical electron microscopy and spectroscopy of biological specimens, polymers, and other beam sensitive materials has been a challenging area due to irradiation damage. There is a pressing need to develop novel imaging and spectroscopic imaging methods that will minimize such sample damage as well as reduce the data acquisition time. The latter is useful for high-throughput analysis of materials structure and chemistry. In this work, we present a novel machine learning based method for dynamic sparse sampling of EDS data using a scanning electron microscope. Our method, based on the supervised learning approach for dynamic sampling algorithm and neural networks based classification of EDS data, allows a dramatic reduction in the total sampling of up to 90%, while maintaining the fidelity of the reconstructed elemental maps and spectroscopic data. We believe this approach will enable imaging and elemental mapping of materials that would otherwise be inaccessible to these analysis techniques.

References

Sep 30, 2005·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·Thomas E Merryman, Jelena Kovacević
Jul 29, 2006·Science·G E Hinton, R R Salakhutdinov
Jan 1, 1991·IEEE Transactions on Neural Networks·D F Specht
Sep 25, 2009·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·Zhongmin Wang, Gonzalo R Arce
Oct 28, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Matthias SeegerBernhard Schölkopf
Mar 1, 2012·Bioinformatics·J VanlierN A W van Riel
May 29, 2015·Nature·Yann LeCunGeoffrey Hinton
Aug 8, 2015·Nature Biotechnology·Yongjin Park, Manolis Kellis
Dec 24, 2016·Journal of Synchrotron Radiation·Nicole M ScarboroughGarth J Simpson

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Citations

Mar 20, 2018·Micron : the International Research and Review Journal for Microscopy·Karl A HujsakVinayak P Dravid

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Related Papers

Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada
Karl HujsakVinayak P Dravid
Journal of Synchrotron Radiation
Nicole M ScarboroughGarth J Simpson
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