Reduced excitatory drive in interneurons in an animal model of cortical dysplasia

Journal of Neurophysiology
Hui XiangS N Roper

Abstract

Cortical dysplasia (CD) is strongly associated with epilepsy. Enhanced excitability in dysplastic neuronal networks is believed to contribute to epileptogenesis, but the underlying mechanisms for the hyperexcitability are poorly understood. Cortical GABAergic interneurons provide the principal inhibition in the neuronal networks by forming inhibitory synapses on excitatory neurons. The aim of the present study was to determine if the function of interneurons in CD is compromised. In a rat model of CD, in utero irradiation, we studied spontaneous and miniature excitatory postsynaptic currents (sEPSCs and mEPSCs) in cortical interneurons using whole cell recording techniques. Two types of interneurons, type I and type II, were identified based on their distinctive spike patterns and short-term synaptic plasticity. We found that the frequencies of sEPSCs and mEPSCs were significantly decreased in both types of interneurons in CD. However, the amplitude and kinetics of sEPSCs and mEPSCs were not different. Five-pulse, 20-Hz stimulation produced short-term depression in type I interneurons in both CD and control tissue. Type II interneurons showed a robust short-term facilitation in both CD and control tissue. Morphological analysis...Continue Reading

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Citations

Nov 19, 2010·Cerebral Cortex·Fu-Wen Zhou, Steven N Roper
Sep 22, 2011·Epilepsia·Fu-Wen ZhouSteven N Roper
May 25, 2012·Epilepsia·Philip A Schwartzkroin, H Jürgen Wenzel
Feb 18, 2011·Journal of Neurophysiology·Daniel L JonesScott C Baraban
Jun 12, 2009·Journal of Neurophysiology·Daniel L Jones, Scott C Baraban
Apr 8, 2015·Journal of Neuroscience Methods·Heiko J Luhmann
Dec 21, 2010·Brain Research·Amanda L George, Kimberle M Jacobs
Sep 29, 2011·Journal of Psychopharmacology·Jihong CuiHui Xiang
Sep 21, 2007·Journal of Neurophysiology·Daniel L Jones, Scott C Baraban
May 5, 2017·Frontiers in Cellular Neuroscience·Asher J AlbertsonJohn J Hablitz

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