Reduced expression of alpha-catenin, beta-catenin, and gamma-catenin is associated with high cell proliferative activity and poor differentiation in non-small cell lung cancer

Journal of Clinical Pathology
R T PirinenV M Kosma

Abstract

To investigate the expression of catenins (alpha, beta, and gamma) in non-small cell lung carcinoma (NSCLC) and its relation to clinicopathological factors and prognosis. The expression of catenins was analysed immunohistochemically in 261 patients with resected NSCLC, diagnosed between 1978 and 1996 in eastern Finland: The cell proliferation index of the tumours was analysed by means of an image analyser. The staining results were compared with clinicopathological characteristics and survival. Normal catenin staining was found significantly more often in adenocarcinomas than in squamous cell carcinomas or anaplastic/large cell carcinomas. Reduced staining of alpha-catenin, beta-catenin, and gamma-catenin was related to poor differentiation of the tumour. The tumours with reduced staining of beta-catenin or gamma-catenin often had higher cell proliferation activity. Nuclear staining of beta-catenin and gamma-catenin was found in 16 (7%) and 29 (13%) cases, respectively. This nuclear staining correlated directly with increased cell proliferation and inversely with membranous staining. In survival analyses the predictors of overall and disease free survival were stage and tumour type. The expression of catenins did not affect sur...Continue Reading

References

Apr 15, 1996·Cancer·H ShiozakiM Monden
Feb 18, 1998·Current Opinion in Oncology·L C Bullions, A J Levine
Apr 16, 1998·Molecular Pathology : MP·J A JankowskiD S Sanders
Apr 16, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K AshidaN Kaibara
May 1, 1998·American Journal of Respiratory and Critical Care Medicine·M A SulzerP H Theunissen
Oct 7, 1998·International Journal of Cancer. Journal International Du Cancer·P HirvikoskiV M Kosma
Mar 10, 1999·Journal of Clinical Pathology·J M ReteraP H Theunissen
Mar 30, 1999·International Journal of Cancer. Journal International Du Cancer·Y KimuraM Monden
Aug 25, 1999·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·W R SmytheS M Albelda
Nov 5, 1999·Molecular Cell Biology Research Communications : MCBRC·F NolletF van Roy

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Citations

Sep 16, 2005·Journal of Cancer Research and Clinical Oncology·Soichi IwaiYoshiaki Yura
Jul 18, 2009·Pathology Oncology Research : POR·Muhammet Emin GuldurKemal Bakir
Nov 10, 2009·Pathology Oncology Research : POR·Andrzej WincewiczMariola Sulkowska
Nov 27, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·K J O'ByrneJ L Jones
Apr 17, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Roy M BremnesWilbur A Franklin
Apr 5, 2012·Molecular and Cellular Biology·Veenu TripathiDrazen B Zimonjic
Jun 9, 2005·Respiration; International Review of Thoracic Diseases·R H J BreuerE F Smit
Mar 31, 2009·American Journal of Respiratory Cell and Molecular Biology·Melanie Königshoff, Oliver Eickelberg
Mar 25, 2006·Future Oncology·Caroline SalonElisabeth Brambilla
Apr 11, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Li DongJian-Ping Xiong
Oct 20, 2007·Seminars in Cancer Biology·Jacqueline M Benjamin, W James Nelson
Jan 1, 2009·International Journal of Cancer. Journal International Du Cancer·Nuray ErinGary A Clawson
Jan 21, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Tero LeinonenVeli-Matti Kosma
Apr 25, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Cheng-Nong GuanPei-Weng Zhang
Mar 31, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Juanjuan CheBangwei Cao
Apr 17, 2015·Reproductive Biology and Endocrinology : RB&E·Annie GirardMarc-André Sirard
Nov 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cheng-Long HuangMasaki Ueno
May 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R M BremnesW A Franklin
Nov 5, 2003·The Journal of Pathology·A S AbutailyW R Roche
Dec 31, 2002·Molecular Reproduction and Development·Chin-Tao TaiGeorge T C Chen
Dec 13, 2002·International Journal of Cancer. Journal International Du Cancer·Cornelia DietrichFranz Oesch
Feb 6, 2015·Journal of Korean Medical Science·Tae-Hyung KimJang Won Sohn
Jul 25, 2007·Journal of Cellular Biochemistry·Yang XiangHui-Jun Liu
Jun 15, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·David BlancoLuis M Montuenga
Apr 7, 2006·Journal of Cellular Biochemistry·M HindiéM-D Nagel

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