Reduced expression of apoptosis-related antigens in thymuses from patients with myasthenia gravis

Immunology Letters
A MasunagaI Sugawara

Abstract

Expression of the apoptosis-related antigens, Fas and BM-1, in thymuses from patients with myasthenia gravis (MG) was examined using immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR). Fas antigen was markedly decreased in lymphoid follicles in thymuses from patients with MG, but was expressed diffusely in the remaining thymus tissues and in neonatal thymuses. BM-1 antigen was not expressed in the lymphoid follicles or other parts of the thymus. Fas mRNA was also decreased to various degrees in the thymuses from MG patients. Therefore, Fas antigen may play an important role in autoimmune diseases including MG.

References

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Citations

Apr 1, 1996·Annals of Neurology·J OnoderaY Itoyama
Jul 1, 1998·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·R Y LinH Menikoff
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Oct 16, 1995·Brain Research·T NishimuraK Kosaka

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