Reduced expression of erythropoietin-producing hepatocyte B6 receptor tyrosine kinase in prostate cancer

Oncology Letters
Elnisr Rashed MohamedKyogo Itoh

Abstract

Loss of erythropoietin-producing hepatocyte (Eph) B6 gene expression is associated with poor prognosis in neuroblastoma, melanoma and other tumors. The present study evaluated the expression of EphB6 receptor tyrosine kinase in normal and prostate cancer tissue using immunohistochemistry. The association between EphB6 expression, clinicopathological findings, proliferating-cell nuclear antigen (PCNA; another prognostic marker) and progression of prostate cancer was analyzed. Tissue microarray samples of normal prostatic tissue and prostate cancer tissue from 46 patients treated with radical prostatectomy for prostate cancer were included in this study. Polyclonal anti-EphB6 and monoclonal anti-PCNA antibodies were used to assess EphB6 and PCNA expression by immunohistochemistry. EphB6 was expressed in normal and prostate cancer tissue; however, its expression was significantly reduced in prostate cancer tissue compared with normal prostatic tissue (P<0.0001), in high volume (≥4 cm(3)) cancer compared with low volume (<4 cm(3); P=0.015), and in pT3 stage compared with pT2 stage of the disease (P=0.0007). No correlation was observed between the expression of EphB6 and PCNA. Short biochemical progression-free survival was associat...Continue Reading

References

Aug 1, 1997·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Q Xu, D G Wilkinson
Feb 8, 2000·The International Journal of Biochemistry & Cell Biology·M Nakamoto
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·X X TangN Ikegaki
Jul 3, 2002·Nature Reviews. Molecular Cell Biology·Klas Kullander, Rüdiger Klein
Dec 10, 2002·Science·G ManningS Sudarsanam
Dec 14, 2002·The International Journal of Biochemistry & Cell Biology·Juha-Pekka Himanen, Dimitar B Nikolov
Aug 11, 2004·Angiogenesis·Dana M Brantley-Sieders, Jin Chen
Sep 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xao X TangNaohiko Ikegaki
Mar 7, 2006·Biochemical and Biophysical Research Communications·Brian P FoxRaj P Kandpal
Feb 25, 2010·Nature Reviews. Cancer·Elena B Pasquale

❮ Previous
Next ❯

Citations

Jan 5, 2018·Oncotarget·Wen LiuAnnika Lindblom
Mar 27, 2021·PloS One·Emilia O MasonJuha P Himanen
Aug 8, 2021·International Journal of Molecular Sciences·Timothy G StrozenBehzad M Toosi
Jul 20, 2020·Toxicon : Official Journal of the International Society on Toxinology·Danielle McCulloughCarol M Trim

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft

Software Mentioned

SPSS

Related Concepts

Related Feeds

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.