Reduced expression of HLA class II molecules and Iinterleukin-10- and transforming growth factor beta1-independent suppression of T-cell proliferation in human cytomegalovirus-infected macrophage cultures

Journal of Virology
J Odeberg, Cecilia Söderberg-Nauclér

Abstract

After a primary infection, human cytomegalovirus (HCMV) establishes lifelong latency in myeloid lineage cells, and the virus has developed several mechanisms to avoid immune recognition and destruction of infected cells. In this study, we show that HCMV utilizes two different strategies to reduce the constitutive expression of HLA-DR, -DP, and -DQ on infected macrophages and that infected macrophages are unable to stimulate a specific CD4+ T-cell response. Downregulation of the HLA class II molecules was observed in 90% of the donor samples and occurred in two phases: at an early (1 day postinfection [dpi]) time point postinfection and at a late (4 dpi) time point postinfection. The early inhibition of HLA class II expression and antigen presentation was not dependent on active virus replication, since UV-inactivated virus induced downregulation of HLA-DR and inhibition of T-cell proliferation at 1 dpi. In contrast, the late effect required virus replication and was dependent on the expression of the HCMV unique short (US) genes US1 to -9 or US11 in 77% of the samples. HCMV-treated macrophages were completely devoid of T-cell stimulation capacity at 1 and 4 dpi. However, while downregulation of HLA class II expression was rathe...Continue Reading

References

Apr 1, 1992·Journal of Virology·P LucinU H Koszinowski
Nov 1, 1991·Reviews of Infectious Diseases·S R RiddellP D Greenberg
Apr 1, 1989·Clinical Microbiology Reviews·B A Forbes
Nov 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·B B Wentworth, L French
Jan 1, 1984·Scandinavian Journal of Infectious Diseases·K Ahlfors
Jan 1, 1995·The Journal of Infectious Diseases·C L Ng-Bautista, D D Sedmak
Mar 1, 1996·Journal of Virology·K N FishJ A Nelson
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·T R JonesH L Ploegh
Feb 1, 1997·Current Opinion in Immunology·J M Boss
Jun 6, 1998·Trends in Microbiology·H HengelU H Koszinowski
Apr 26, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C CerboniE Carbone

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Citations

Jan 29, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christophe Legendre, Manuel Pascual
Nov 3, 2006·Journal of Virology·Emmanuel J WiertzMaaike E Ressing
Jan 13, 2009·Virology Journal·Mindy Miller-Kittrell, Tim E Sparer
Aug 4, 2010·Pediatric Hematology and Oncology·Gunseli BozdoganYildiz Yildirmak
Sep 30, 2014·Cellular & Molecular Immunology·Pero LučinMaja Ilić Tomaš
Sep 25, 2004·Medicinal Research Reviews·Jindrich CinatlHans Wilhelm Doerr
Mar 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chris A BenedictEdith M Janssen
Jul 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emmanuelle Le RoyJean-Luc Davignon
Jun 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shahram Salek-ArdakaniJohn R Arrand
Sep 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew W LeeElizabeth D Mellins

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