PMID: 9558492Apr 29, 1998Paper

Reduced expression of mRNA for transforming growth factor beta (TGF beta) and TGF beta receptors I and II and decreased TGF beta binding to the receptors in in vitro-aged fibroblasts

Archives of Dermatological Research
Y MoriH Ueki

Abstract

Previous studies have demonstrated that the expression of type I collagen, the most abundant protein in the dermis, is reduced in in vitro-aging fibroblast cultures, but the mechanism controlling the reduction of type I collagen expression is not understood. Recent studies, however, have demonstrated that transforming growth factor beta (TGF beta) plays an important role in the regulation of type I collagen expression. The purpose of this study was to investigate the role of TGF beta in downregulation of type I collagen expression in in vitro-aged fibroblasts. We compared the expression of mRNA for alpha 1 (I) collagen, TGF beta, TGF beta type I receptor and TGF beta type II receptor in early and late-passage fibroblasts by Northern blot hybridizations. The mRNA levels of alpha 1(I) collagen, TGF beta, and TGF beta receptors I and II in late-passage fibroblasts were reduced to 62%, 62%, 59% and 59%, respectively, of those in early-passage fibroblasts. We also compared TGF beta receptor binding in early- and late-passage fibroblasts using receptor binding assays. The affinity of 125I-TGF beta in late-passage fibroblasts was lower than that in early-passage fibroblasts. These results suggest that the reduction of type I collagen ...Continue Reading

Citations

Jun 18, 2011·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·E Makrantonaki, C C Zouboulis
Sep 5, 2002·Ageing Research Reviews·Laure Rittié, Gary J Fisher
Jun 14, 2000·Plastic and Reconstructive Surgery·H P LorenzM T Longaker
Jul 9, 2003·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Stefan Schultze-MosgauGerhard G Grabenbauer
Apr 27, 2007·Dermatology : International Journal for Clinical and Investigative Dermatology·Evgenia Makrantonaki, Christos C Zouboulis
Nov 2, 2011·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Peter ElsnerChristos C Zouboulis
Oct 18, 2018·Aesthetic Plastic Surgery·Xiaoxuan LeiBiao Cheng
Aug 12, 2004·Free Radical Biology & Medicine·Kristin K Nelson, J Andres Melendez
Jun 30, 2009·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·P J PappasW N Durán
Dec 15, 2010·Clinics in Dermatology·Christos C Zouboulis, Evgenia Makrantonaki

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