Reduced expression of plakoglobin indicates an unfavorable prognosis in subsets of patients with non-small-cell lung cancer

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
K PantelG Riethmüller

Abstract

Plakoglobin is thought to play a key role in cadherin-mediated epithelial cell adhesion, because it is a common component of desmosomal and nondesmosomal adherens junctions. Because loss of homotypic cell adhesion is an important early step in invasion and metastasis of solid tumors, we evaluated the frequency and prognostic significance of a deficient expression of plakoglobin in human lung cancer. At primary surgery, representative specimens of the primary tumor were obtained from 96 consecutive patients with completely resected non-small-cell lung carcinoma (NSCLC) without overt distant metastases. Cryostat sections of these specimens and metastatic lymph nodes were stained with monoclonal antibody (mAb) PG 5.1 against plakoglobin, using an immunoperoxidase technique. Patients were monitored for a median of 39 months (range, 12 to 56) after surgery. Absent or severely reduced expression of plakoglobin (ie, < 30% positive tumor cells) was observed in 39 patients (40.6%). There was no significant correlation to established risk factors, such as the histology, extension, and histologic grade of the primary tumor and metastatic lymph node involvement, or expression of alpha-catenin. Expression of plakoglobin in lymph node metast...Continue Reading

Citations

Jan 3, 2001·The Journal of Clinical Endocrinology and Metabolism·J BöhmV M Kosma
Oct 26, 2002·Leukemia·S PolychronopoulouS A Haidas
Jun 24, 2008·Fetal and Pediatric Pathology·Gordana Basta-JovanovicDejan Arsic
Feb 6, 2015·Journal of Korean Medical Science·Tae-Hyung KimJang Won Sohn
Nov 16, 2014·EMBO Molecular Medicine·Simon A JoosseKlaus Pantel
Jul 23, 2015·Journal of Hematology & Oncology·Niraj ShenoyAmit Verma
Jun 9, 2015·Oncogene·K Pantel, M R Speicher
Oct 16, 1999·International Journal of Cancer. Journal International Du Cancer·J HusmarkM Nilsson
Sep 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Svetlana MukhinaPeter E Lobie
Nov 3, 2011·PloS One·Qi WeiHayden Huang
Jul 13, 2017·Molecular Oncology·Elisabeth Katharina TrappMarianna Alunni-Fabbroni
May 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R M BremnesW A Franklin
May 21, 2013·Journal of Cell Science·Zackie AktaryManijeh Pasdar
Apr 17, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Geoffrey D YoungRobert I Garver
Apr 17, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Roy M BremnesWilbur A Franklin
Jul 26, 2003·The Journal of Investigative Dermatology·Peiqi HuDavid S Rubenstein

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