Reduced Expression of the Antigen Processing Machinery Components TAP2, LMP2, and LMP7 in Tonsillar and Base of Tongue Cancer and Implications for Clinical Outcome

Translational Oncology
Nikolaos TertipisTorbjörn Ramqvist

Abstract

Patients with human papillomavirus (HPV)-positive tonsillar squamous cell carcinoma (TSCC) and base of tongue squamous cell carcinoma (BOTSCC) have a better clinical outcome than those with corresponding HPV-negative tumors. Moreover, there is a strong positive correlation between absent/low as opposed to strong HLA class I expression and favorable clinical outcome for HPV-positive tumors, while the reverse applies to HPV-negative tumors. The expression of the antigen processing machinery (APM) components TAP1, TAP2, LMP2, and LMP7 in these tumors in relation to HPV status, HLA class I expression, each other, and clinical outcome was therefore investigated. Formalin-fixed paraffin-embedded TSCC and BOTSCC, derived from 151 patients and previously analyzed for HPV DNA, HLA class I, and LMP10 expression were stained by immunohistochemistry for TAP1, TAP2, LMP2, and LMP7. Absent/low TAP2, LMP2, and LMP7 expression, similar to HLA class I and LMP10, was common in TSCC and BOTSCC, irrespective of HPV status. Expression of TAP1 and TAP2 was correlated, as was LMP2 to LMP7. LMP2 and LMP7 expression was also associated to HLA class I expression. Moreover, absence of LMP7 was linked to increased disease-free survival in both HPV-positiv...Continue Reading

References

Oct 1, 1993·Human Molecular Genetics·F LarsenH Prydz
Jan 1, 1996·Annual Review of Immunology·I A York, K L Rock
Apr 9, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Markus MeissnerBarbara Seliger
Sep 23, 2006·International Journal of Cancer. Journal International Du Cancer·Lalle HammarstedtEva Munck-Wikland
Sep 25, 2007·The Laryngoscope·Joel A ErnsterMichael Mathews
Feb 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anil K ChaturvediMaura L Gillison
Mar 31, 2009·International Journal of Cancer. Journal International Du Cancer·Anders NäsmanTina Dalianis
Oct 27, 2009·International Journal of Cancer. Journal International Du Cancer·Per AttnerEva Munck-Wikland
Oct 30, 2010·Emerging Infectious Diseases·Torbjörn Ramqvist, Tina Dalianis
Nov 1, 2011·International Journal of Cancer. Journal International Du Cancer·Per AttnerLinda Marklund
Nov 29, 2011·Cancer Immunology, Immunotherapy : CII·Barbara Seliger
Feb 22, 2012·Translational Oncology·Alessandra FavoleEnrico Bollo
Mar 3, 2012·Cellular and Molecular Life Sciences : CMLS·Frédéric EbsteinUlrike Seifert
May 18, 2012·International Journal of Cancer. Journal International Du Cancer·Anders NäsmanTorbjörn Ramqvist
Jul 13, 2012·Head and Neck Pathology·Anil K Chaturvedi
Apr 11, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Cecilia NordforsTina Dalianis
Nov 20, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anil K ChaturvediMaura L Gillison

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Citations

Mar 25, 2015·Viruses·Torbjörn RamqvistTina Dalianis
Mar 29, 2018·International Journal of Molecular Sciences·Torbjörn RamqvistEva Munck-Wikland
Apr 27, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Vassiliki SalouraYusuke Nakamura
Nov 21, 2017·Cancer Letters·Sanjay KumarManoj Mishra

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Methods Mentioned

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