PMID: 8960982Oct 1, 1996Paper

Reduced expression of voltage-gated sodium channels in neurons cultured from trisomy 16 mouse hippocampus

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
J Stoll, Zygmunt Galdzicki

Abstract

Voltage-gated sodium channels are responsible for the initial depolarizing phase of the action potential. In hippocampal neurons cultured from trisomy 16 (Ts16) mice (a model for Down's syndrome), the maximum inward conductance mediated by these channels was reduced 47% relative to control diploid neurons. This reduced conductance was reflected in a 35% decrease in binding of radiolabeled saxitoxin, a sodium channel-specific ligand, indicating expression of fewer channels in these neurons. The mRNAs encoding the alpha and beta 1 subunits were, however, present at the same levels in Ts16 neurons and control diploid neurons. Thus, the altered regulation of voltage-gated sodium channels in Ts16 neurons is apparently a post-transcriptional event and possible mechanisms are discussed.

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Citations

Oct 6, 1997·Neuroscience Letters·R J SiareyZ Galdzicki
May 5, 2001·Brain Research. Brain Research Reviews·Z GaldzickiS I Rapoport
Apr 26, 2011·Toxicology and Applied Pharmacology·Ranjana VermaZygmunt Galdzicki
May 2, 2006·Journal of Physiology, Paris·Katherine SaudPablo Caviedes
Jul 2, 2002·Journal of Neurophysiology·H Nadeau, H A Lester

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