PMID: 9443656Jan 27, 1998Paper

Reduced extracellular levels of serotonin in the amygdala of androgenized female rats

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
C Sundblad, E Eriksson

Abstract

The object of this study was to evaluate the effect of androgenization on the extracellular concentrations of serotonin in the amygdala of otherwise intact female rats. One group of animals received one high dose of testosterone (1 mg, s.c.) within three hours after birth, one group received continuous administration of testosterone by means of silicone tubings (50 mm) for approximately 20 days starting at day 40, and one group received testosterone both in the neonatal period and from day 40 and onwards. Assessment of extracellular levels of serotonin in the amygdala was undertaken around day 60 using in vivo microdialysis with HPLC detection; the animals were awake and unrestrained during the microdialysis procedure. Dialysate serotonin concentrations did not differ between the three groups of androgenized animals; however, in all three groups, dialysate levels of serotonin were significantly lower than in controls receiving sesame oil neonatally and empty tubings at day 40. It is suggested that the effects of testosterone on sex-dependent behaviours such as aggression and sexual activity may be at least partly due to a reduction in brain serotonin function.

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Citations

May 18, 2013·Psychopharmacology·Jakob NäslundElias Eriksson
Aug 2, 2002·Pharmacology, Biochemistry, and Behavior·Jill M Grimes, Richard H Melloni
Feb 3, 1999·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·O BingE Eriksson
Nov 4, 2008·Autonomic Neuroscience : Basic & Clinical·Gordana LeposavićDusko Kosec
Sep 27, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M A de Souza SilvaJ P Huston
Nov 28, 2006·Psychoneuroendocrinology·Kathleen PajerYun Wang
Aug 23, 2006·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·C JacobsP Simoens
Feb 19, 2014·Biological Reviews of the Cambridge Philosophical Society·Konstantin ChichinadzeMarina Nikolaishvili
Feb 22, 2012·Psychiatry Research·Baris O Yildirim, Jan J L Derksen
Nov 2, 2016·Hormone Molecular Biology and Clinical Investigation·Nirja K Chaudhari, Laxmipriya P Nampoothiri

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