Reduced fibre size, capillary supply and mitochondrial activity in constitutional thinness' skeletal muscle

Acta Physiologica
Bogdan GaluscaNatacha Germain

Abstract

Constitutional thinness (CT) is a rare condition of natural low body weight, with no psychological issues, no marker of undernutrition and a resistance to weight gain. This study evaluated the skeletal muscle phenotype of CT women by comparison with a normal BMI control group. Ten CT women (BMI < 17.5 kg/m2 ) and 10 female controls (BMI: 18.5-25 kg/m2 ) underwent metabolic and hormonal assessment along with muscle biopsies to analyse the skeletal muscular fibres pattern, capillarity, enzymes activities and transcriptomics. Constitutional thinness displayed similar energy balance metabolic and hormonal profile to controls. Constitutional thinness presented with lower mean area of all the skeletal muscular fibres (-24%, P = .01) and percentage of slow-twitch type I fibres (-25%, P = .02, respectively). Significant downregulation of the mRNA expression of several mitochondrial-related genes and triglycerides metabolism was found along with low cytochrome c oxidase (COX) activity and capillary network in type I fibres. Pre- and post-mitochondrial respiratory chain enzymes levels were found similar to controls. Transcriptomics also revealed downregulation of cytoskeletal-related genes. Diminished type I fibres, decreased mitochondri...Continue Reading

References

Feb 1, 1976·Journal of Applied Physiology·D L CostillB Saltin
Apr 7, 1990·Lancet·A J WadeJ M Round
Aug 1, 1981·Clinical Physiology·B EssénB Saltin
Dec 1, 1994·The American Journal of Physiology·V SmerduS Schiaffino
Aug 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J A Simoneau, C Bouchard
May 1, 1995·Journal of Applied Physiology·M Y ZhouP D Gollnick
Jan 1, 1997·Journal of Applied Physiology·H E BergP A Tesch
Jul 3, 1998·Acta Neuropathologica·D M McLoughlinG F Russell
Jan 5, 2002·Differentiation; Research in Biological Diversity·A AsakuraM Rudnicki
May 15, 2002·American Journal of Physiology. Endocrinology and Metabolism·Charles J TannerJoseph A Houmard
Jul 18, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·C M Bulik, D B Allison
Jan 10, 2003·The Journal of Clinical Endocrinology and Metabolism·Virginie TolleBruno Estour
May 12, 2004·Journal of Molecular Biology·Snezana KojicGeorgine Faulkner
Aug 26, 2004·PLoS Biology·Yong-Xu WangRonald M Evans
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
Feb 24, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mark W HamrickJohn McCormick
May 2, 2006·Statistical Applications in Genetics and Molecular Biology·Gordon K Smyth
Aug 17, 2006·American Journal of Physiology. Endocrinology and Metabolism·Cécile BossuBruno Estour
Apr 19, 2007·European Journal of Clinical Nutrition·S E CrouterD R Bassett
Apr 26, 2007·JAMA : the Journal of the American Medical Association·Patrick KortebeinWilliam J Evans
Oct 25, 2007·The Journal of Clinical Endocrinology and Metabolism·Bogdan GaluscaBruno Estour
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Feb 9, 2013·The Journal of Clinical Endocrinology and Metabolism·Fabrizio PasanisiFranco Contaldo
Aug 26, 2014·Cytoskeleton·Sobia Iqbal, David A Hood
Mar 17, 2015·The American Journal of Pathology·Marion RavelojaonaLaurent A Messonnier
Apr 10, 2017·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Yehui DuanYulong Yin

❮ Previous
Next ❯

Citations

Aug 3, 2019·The American Journal of Clinical Nutrition·Yiin LingNele Gheldof
Jun 2, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Mélina BaillyJulien Verney
Apr 24, 2020·The British Journal of Nutrition·Mélina BaillyJulien Verney
Apr 11, 2020·Journal of Cachexia, Sarcopenia and Muscle·Yiin LingNatacha Germain
Mar 28, 2021·European Journal of Clinical Nutrition·Mélina BaillyJulien Verney
May 1, 2021·Reviews in Endocrine & Metabolic Disorders·Mélina BaillyJulien Verney

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.