Reduced focal fiber collinearity in the cingulum bundle in adults with obsessive-compulsive disorder

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
A VersaceM L Phillips

Abstract

Obsessive-compulsive disorder (OCD) is a disabling condition, often associated with a chronic course. Given its role in attentional control, decision-making, and emotional regulation, the anterior cingulate cortex is considered to have a key role in the pathophysiology of the disorder. Notably, the cingulum bundle, being the major white matter tract connecting to this region, has been historically a target for the surgical treatment of intractable OCD. In this study, we aimed to identify the extent to which focal-more than diffuse-abnormalities in fiber collinearity of the cingulum bundle could distinguish 48 adults with OCD (mean age [SD] = 23.3 [4.5] years; F/M = 30/18) from 45 age- and sex-matched healthy control adults (CONT; mean age [SD] = 23.2 [3.8] years; F/M = 28/17) and further examine if these abnormalities correlated with symptom severity. Use of tract-profiles rather than a conventional diffusion imaging approach allowed us to characterize white matter microstructural properties along (100 segments), as opposed to averaging these measures across, the entire tract. To account for these 100 different segments of the cingulum bundle, a repeated measures analysis of variance revealed a main effect of group (OCD < CONT;...Continue Reading

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Citations

Sep 22, 2020·Biological Psychiatry·Suzanne N HaberSaad Jbabdi
Feb 12, 2021·Journal of Behavioral Addictions·Małgorzata DrapsMateusz Gola

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Software Mentioned

AFQ
Trio
eddy
Prisma
SPSS
FMRIB Software Library ( FSL
Automated Fiber Quantification ( AFQ )
topup
R
Automated Quantification ( AFQ

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