Reduced folate carrier-1 80G > A gene polymorphism is not associated with methotrexate treatment response in South Indian Tamils with rheumatoid arthritis

Clinical Rheumatology
N MuralidharanV S Negi

Abstract

Methotrexate (MTX) is the most commonly used disease-modifying drug to treat rheumatoid arthritis (RA). Although there are no reliable molecular markers to predict the treatment response and adverse effects to MTX therapy, the polymorphisms in genes coding for MTX metabolizing enzymes and transporters may play a crucial role. The reduced folate carrier-1 (RFC-1) is a bidirectional anion exchanger which transports MTX and folinic acid. It is reported to influence MTX treatment response and adverse effects in some ethnic populations but not in others. It is also associated with susceptibility to various diseases including systemic lupus erythematosus (SLE). The present study was aimed at investigating the role of RFC-1 80G > A gene polymorphism in association with disease susceptibility, MTX treatment response and the MTX-induced adverse events in the South Indian Tamil patients with rheumatoid arthritis. The RFC-1 80G > A gene polymorphism was investigated in 327 patients with RA and in 322 healthy controls by PCR-RFLP method. It was found that the heterozygous RFC-1 80 GA genotype was associated with protection against RA [p = 0.02, odds ratio (OR) 0.69, 95 % confidence interval (CI) 0.50-0.95]. However, it was not found to be ...Continue Reading

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Citations

Jun 9, 2016·Journal of Pharmaceutical Health Care and Sciences·Masayuki HashiguchiMayumi Mochizuki
Oct 11, 2017·Genetic Testing and Molecular Biomarkers·Mirna Gisel González-MercadoIngrid P Dávalos
Oct 19, 2019·The Pharmacogenomics Journal·Frank EektimmermanHenk-Jan Guchelaar
Dec 12, 2018·Epigenetics : Official Journal of the DNA Methylation Society·Tamsyn M Uren WebsterSofia Consuegra
Sep 22, 2018·The Pharmacogenomics Journal·Andrea Giletti, Patricia Esperon

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