PMID: 9430615Jan 31, 1998Paper

Reduced food intake in zinc deficient rats is normalized by megestrol acetate but not by insulin-like growth factor-I

The Journal of Nutrition
J D BrowningB L O'Dell

Abstract

Zinc deficiency in rats results in impaired growth accompanied by decreased and cyclic food intake. These signs are associated with decreased plasma insulin-like growth factor-I (IGF-I), a major mediator of growth. The purpose of this study was to determine the relationship between decreased plasma IGF-I and the impairment of appetite and growth in zinc deficiency. Immature male rats were fed free choice a low zinc (<1 mg/kg) diet (-Zn) or a zinc adequate (100 mg/kg) control diet (+Zn). Plasma IGF-I concentrations were normalized in zinc-deficient rats by the following two methods: osmotic pump infusion of IGF-I (2.4 mg/kg body weight daily) and oral administration (50 mg/kg body weight twice daily) of the synthetic progestin, megestrol acetate (MA). Infusion of IGF-I for 8 d sustained plasma IGF-I concentrations in zinc-deficient rats at control levels but had no effect on either food intake or growth rate. MA administration for 8 d maintained the plasma IGF-I of deficient rats and significantly increased food intake. The early aspects of cyclic food intake were eliminated, and, after a few days, food intake of deficient rats given MA was not different than that of controls. MA increased food intake and fat deposition regardle...Continue Reading

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Citations

Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·A Van Gossum, J Neve
May 10, 2000·The Journal of Nutrition·R S MacDonald
Jul 2, 2005·Journal of Pediatric Gastroenterology and Nutrition·Andrew G HallAnthony F Philipps
Apr 4, 2002·Nutritional Neuroscience·P S WilliamsonR S Macdonald
May 18, 2020·Current Osteoporosis Reports·Holly L Racine, Maria A Serrat
Sep 25, 2002·Canadian Journal of Physiology and Pharmacology·Shirley C Paski, Zhaoming Xu
Jan 1, 2000·Nutritional Neuroscience·B L O'dell, J D Browning
Oct 24, 2007·The Journal of Nutrition·Huiyun ShenBernhard Hennig
Apr 21, 2010·Experimental Biology and Medicine·Lynn A HannaCarl L Keen
May 10, 2000·The Journal of Nutrition·N F Shay, H F Mangian
Apr 25, 2000·Biochemical and Biophysical Research Communications·M A Jankowski-HennigC L Keen

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