Reduced fractional anisotropy on diffusion tensor magnetic resonance imaging after hypoxic-ischemic encephalopathy

Pediatrics
Phil WardMary Rutherford

Abstract

Apparent diffusion coefficients (ADC) that are measured by diffusion-weighted imaging are reduced in severe white matter (WM) and in some severe basal ganglia and thalamic (BGT) injury in infants who present with hypoxic-ischemic encephalopathy (HIE). However, ADC values may pseudonormalize or even be high during this time in some less severe but clinically significant injuries. We hypothesized that fractional anisotropy (FA), a measure of the directional diffusivity of water made using diffusion tensor imaging, may be abnormal in these less severe injuries; therefore, the objective of this study was to use diffusion tensor imaging to measure ADC and FA in infants with moderate and severe hypoxic-ischemic brain injury. Twenty infants with HIE and 7 normal control infants were studied. All infants were born at >36 weeks' gestational age, and MRI scans were obtained within 3 weeks of delivery. Data were examined for normality, and comparisons were made using analysis of variance or Kruskal-Wallis as appropriate. During the first week, FA values were decreased with both severe and moderate WM and BGT injury as assessed by conventional imaging, whereas ADC values were reduced only in severe WM injury and some severe BGT injury. Abn...Continue Reading

Citations

Jun 30, 2010·Neuroradiology·Leonardo Guilhermino GutierrezLeandro Tavares Lucato
Jul 24, 2008·Pediatric Radiology·Thierry A G M Huisman, Aylin Tekes
May 1, 2010·Pediatric Radiology·Mary RutherfordFrances Cowan
Apr 23, 2010·Pediatric Radiology·Monica EpelmanSusan Blaser
Sep 22, 2011·Pediatric Radiology·Monica EpelmanSusan I Blaser
Feb 3, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Charlotte de LangeBerit H Munkeby
May 8, 2008·Current Neurology and Neuroscience Reports·Joseph Scafidi, Vittorio Gallo
Jun 20, 2013·European Journal of Radiology·QiangQiang GangYikai Xu
Jan 15, 2008·Journal de gynécologie, obstétrique et biologie de la reproduction·V Zupan Simunek
Sep 17, 2013·Seminars in Fetal & Neonatal Medicine·Ericalyn Kasdorf, Jeffrey M Perlman
Sep 12, 2009·Journal of Child Neurology·Fadoua Saadani-MakkiDiane Chugani
Feb 15, 2013·Orphanet Journal of Rare Diseases·Valentina CittonPietro Maffei
Mar 17, 2009·Pediatric Research·Alan R BarnetteTerrie E Inder
Apr 15, 2010·Neuroradiology·Linda S de Vries, Floris Groenendaal
Jul 16, 2014·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Sonia K GheiIzlem Izbudak
Jul 4, 2007·Topics in Magnetic Resonance Imaging : TMRI·Diana P Rodriguez, Tina Young Poussaint
Nov 5, 2008·Clinical Obstetrics and Gynecology·Joshua S ShimonyTerrie E Inder
Mar 1, 2011·Expert Opinion on Medical Diagnostics·Topun Austin, Helen O'Reilly
Dec 14, 2011·Medical Image Analysis·Feng YangPeter B Kingsley
Nov 16, 2011·Magnetic Resonance Imaging Clinics of North America·Izlem Izbudak, P Ellen Grant
Sep 20, 2011·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·D BlancoUNKNOWN Comisión de Estándares de la Sociedad Española de Neonatología (SEN)
Jun 7, 2011·Neuroimaging Clinics of North America·Steve H FungPamela W Schaefer
Sep 25, 2010·Early Human Development·Miriam Martinez-BiargeFrances M Cowan
Aug 3, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Sachiko IwataOsuke Iwata
Jan 30, 2010·Seminars in Perinatology·Serena J CounsellMary A Rutherford
Sep 15, 2009·Pediatric Neurology·Jacqueline S CoatsStephen Ashwal
Jun 10, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Kevin C ChanEd X Wu
Feb 17, 2009·Pediatric Neurology·Vann ChauSteven Paul Miller
Dec 10, 2008·NeuroImage·Angelos BarmpoutisBaba C Vemuri
Dec 7, 2007·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Akihisa OkumuraKazuyoshi Watanabe
Jun 21, 2012·Journal of Neuroscience Research·Rajesh KumarRonald M Harper
Apr 3, 2010·Seminars in Fetal & Neonatal Medicine·Denis Azzopardi, A David Edwards
Jul 4, 2015·AJNR. American Journal of Neuroradiology·S KwanP Wintermark
Dec 11, 2014·Developmental Medicine and Child Neurology·An N MassaroCatherine Limperopoulos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Basal Ganglia Cerebrovascular Disease

Basal ganglia cerebrovascular disease is a condition where the blood vessels in the basal ganglia are damaged or malfunction. Discover the latest research on basal ganglia cerebrovascular disease here.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.