Reduced free protein S levels in patients with inflammatory bowel disease: prevalence, clinical relevance, and role of anti-protein S antibodies

Digestive Diseases and Sciences
S SaibeniR de Franchis

Abstract

We evaluated free plasma levels of protein S, a natural anticoagulant factor, the prevalence of anti-protein S antibodies, a possible cause of protein S deficiency, and their correlation with anti-phospholipid antibodies in 53 patients with inflammatory bowel disease (IBD) and 53 age- and sex-matched controls. Mean free plasma protein S levels (+/- SD) were significantly lower in IBD patients (0.98+/-0.32 IU/ml) than in controls (1.06+/-0.28 IU/ml) (P < 0.05); only one patient showed protein S deficiency. Specific antibodies to protein S were found in four IBD patients (7.5%) and in one control (1.9%) (P = NS). Five IBD patients (9.4%) and none of the controls showed anti-phospholipid antibodies (P < 0.06). No correlation was found between free protein S levels and anti-protein S antibodies or between anti-protein S and anti-phospholipid antibodies. In conclusion, free plasma protein S levels are slightly but significantly decreased in IBD patients. The prevalence of anti-protein S and antiphospholipid antibodies is increased in IBD patients. Anti-protein S antibodies do not appear to determine low protein S levels or to overlap with or belong to anti-phospholipid antibodies.

Citations

Jun 17, 2015·World Journal of Gastroenterology : WJG·Nora SipekiMaria Papp
Dec 31, 2009·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Basak CakalAysel Ulker
Apr 17, 2013·International Journal of Colorectal Disease·Simone SaibeniMiquel Sans
May 23, 2014·Inflammatory Bowel Diseases·Carla V RothlinSourav Ghosh
Apr 17, 2015·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Imen KraiemHadef Skouri
Jan 20, 2018·BMJ Case Reports·Camila C SimoesHeather L Stevenson
Nov 15, 2006·The American Journal of Gastroenterology·Silvio DaneseMaurizio Vecchi
Dec 13, 2012·Journal of Pediatric Gastroenterology and Nutrition·Cade M NylundLee A Denson
Apr 14, 2015·Thrombosis Journal·Martina GiannottaMonica Milla
Aug 30, 2005·Annals of the New York Academy of Sciences·Gilad TwigYehuda Shoenfeld
May 15, 2013·Journal of Gastroenterology and Hepatology·Victoria P TanPeter R Gibson
Oct 7, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Peter M IrvingDavid S Rampton
Aug 29, 2021·Nature Reviews. Gastroenterology & Hepatology·Pablo A OliveraLaurent Peyrin-Biroulet

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