Reduced frequency of peripheral dendritic cells in type 2 diabetes

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
C C SeifarthI A Harsch

Abstract

It is a common clinical experience that type 2 diabetic patients are susceptible to opportunistic infections. The underlying reasons for this immune deficiency are not yet understood. Dendritic cells (DC) play a key role in initiating innate and adapted immune responses. In order to investigate changes in the DC compartment in the peripheral blood in type 2 diabetes, we analyzed blood from patients under poor and good metabolic control and compared them to healthy controls. 5 mls of blood were collected from 15 healthy controls, 15 diabetic patients with an HbA1c <7.0 and 15 patients with an HbA1c >9.5%. Age range was 44-80 years. Patients were age-matched with the control group. Blood DC were enumerated by flow cytometry after staining with antibodies against the blood dendritic cells antigens 1-3 (BDCA 1-3). This allows quantification of the DC subtypes: myeloid dendritic cells type 1 (mDC1, mDC2) and plasmacytoid dendritic cells (pDC). The relative and absolute frequency for both mDC1 and pDC was clearly diminished in patients with poor metabolic control as compared to healthy controls. In patients with good metabolic control the reduction of DC was less pronounced but still significant, particularly for mDC1. Hyperglycemic ...Continue Reading

Citations

Mar 20, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Masumi TominagaNaoto Nakumura
Apr 18, 2014·Journal of Immunology Research·Ana L Guadarrama-LópezBeatríz E Martínez-Carrillo
Sep 22, 2019·Oral Diseases·Mariana de Sousa RabeloCristiano Susin
Apr 28, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Therese VallerskogHardy Kornfeld
Aug 15, 2020·Frontiers in Immunology·Gholamreza DaryaborKurosh Kalantar
Oct 6, 2020·Frontiers in Endocrinology·Eline Constance Brombacher, Bart Everts
Apr 2, 2021·International Reviews of Immunology·Yuting SunDongping Yuan

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