Reduced GABAA receptor density contralateral to a potentially epileptogenic MRI abnormality in a patient with complex partial seizures

European Journal of Nuclear Medicine
T KuwertO Schober

Abstract

Imaging cerebral GABAA receptor density (GRD) with single-photon emission tomography (SPET) and iodine-123 iomazenil is highly accurate in lateralizing epileptogenic foci in patients with complex partial seizures of temporal origin. Limited knowledge exists on how iomazenil SPET compares with magnetic resonance imaging (MRI) in this regard. We present a patient with complex partial seizures in whom MRI had identified an arachnoid cyst anterior to the tip of the left temporal lobe. Contralaterally to this structural abnormality, interictal electroencephalography (EEG) performed after sleep deprivation disclosed an intermittent frontotemporal dysrhythmic focus with slow and sharp waves. On iomazenil SPET images GRD was significantly reduced in the right temporal lobe and thus contralaterally to the MRI abnormality, but ipsilaterally to the pathological EEG findings. These data suggest that iomazenil SPET may significantly contribute to the presurgical evaluation of epileptic patients even when MRI identifies potentially epileptogenic structural lesions.

References

Sep 1, 1992·Veterinary Surgery : VS·J WallaceA K Patnaik
Aug 1, 1992·The Australian and New Zealand Journal of Surgery·J P FletcherP A Ockelford
Jul 1, 1991·Nuclear Medicine Communications·P A SchubigerE Moser
Aug 1, 1990·Acta Neurologica Scandinavica·S PasseroB Volpini
Mar 1, 1981·Journal of Neurosurgery·L M AuerH Lechner
Jun 1, 1993·Nuclear Medicine Communications·J T KuikkaH Kiiliänen
Mar 1, 1964·Brain : a Journal of Neurology·R G ROBINSON
Aug 1, 1960·Electroencephalography and Clinical Neurophysiology·D SILVERMAN

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Citations

Feb 24, 2006·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Juan F Martínez-LageJuan A Nuño de la Rosa

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