Reduced GABAergic cortical inhibition in aging and depression

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Jennifer I LissemoreDaniel M Blumberger

Abstract

The neurobiology underlying depression in older adults is less extensively evaluated than in younger adults, despite the putative influence of aging on depression neuropathology. Studies using transcranial magnetic stimulation (TMS), a neurophysiological tool capable of probing inhibitory and excitatory cortical neurotransmission, have identified dysfunctional GABAergic inhibitory activity in younger adults with depression. However, GABAergic and glutamatergic cortical neurotransmission have not yet been studied in late-life depression (LLD). Here, we used single- and paired-pulse TMS to measure cortical inhibition and excitation in 92 LLD patients and 41 age-matched healthy controls. To differentiate the influence of age and depression, we also compared these TMS indices to those of 30 younger depressed adults and 30 age- and sex-matched younger healthy adults. LLD patients, older healthy adults, and younger depressed adults demonstrated significantly lower GABAA receptor-mediated cortical inhibition than younger healthy controls. By contrast, no significant differences in cortical inhibition were observed between older adults with and without depression. No significant differences in GABAB receptor-mediated inhibition or cort...Continue Reading

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Citations

Feb 16, 2019·The American Journal of Psychiatry·Tyler S KasterDaniel M Blumberger
May 10, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jennifer I LissemoreDaniel M Blumberger
Jul 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Linn Samira Mari EvensethIngebrigt Sylte
Jul 8, 2020·Molecular Psychiatry·Chien-Wei LinEtienne Sibille
Aug 10, 2019·Frontiers in Molecular Neuroscience·Tija C Jacob
Feb 1, 2021·Cell Calcium·Carola I RadulescuSamuel J Barnes
Jul 27, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Jennifer I LissemoreDaniel M Blumberger
Jul 24, 2021·Seizure : the Journal of the British Epilepsy Association·Sara GaspariniUNKNOWN Epilepsy Study Group of the Italian Neurological Society
Jul 18, 2021·Brain : a Journal of Neurology·Shahram BahramiOle A Andreassen

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