Reduced glioma infiltration in Src-deficient mice

Journal of Neuro-oncology
Caren V LundBrian P Eliceiri


Malignant brain tumors, such as glioblastoma, are characterized by extensive angiogenesis and permeability of the blood-brain barrier (BBB). The infiltration of glioma cells away from the primary tumor mass is a pathological characteristic of glial tumors. The infiltrating tumor cells represent a significant factor in tumor recurrence following surgical debulking, radiation, and chemotherapy treatments. Vascular endothelial growth factor (VEGF)-mediated vascular permeability (VP) has been associated with the progression of glioma tumor growth and infiltration into surrounding normal brain parenchyma. While VEGF induces a robust VP response in control mice (src+/+ or src+/-), the VP response is blocked in src-/- mice that demonstrate a 'leakage-resistant phenotype' in the brain. We used the Src-deficient mouse model to determine the role of Src in the maintenance of the BBB following orthotopic implantation and growth of glioma cells in the brain. Although solid tumor growth was the same in control and src-/- mice, the infiltrating component of glioma growth was reduced in src-/- mice. Characterization of the expression and localization of the extracellular matrix (ECM) protein fibrinogen was evaluated to determine the effect of...Continue Reading


Aug 1, 1985·Circulation Research·M W Bradbury
Feb 1, 1986·Journal of Neurosurgery·R SawayaJ M Tew
Jan 1, 1987·Acta neurochirurgica·K YumitoriK Yamamura
Sep 15, 1995·International Journal of Cancer. Journal International Du Cancer·P H PedersenR Bjerkvig
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J ChenF W Alt
Jul 1, 1996·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·H BárdosR Adány
Dec 5, 1998·CA: a Cancer Journal for Clinicians·M D PradosC B Wilson
Jul 1, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·F MazurierH de Verneuil
Oct 9, 1999·Journal of Neuropathology and Experimental Neurology·Candece L Gladson
Aug 10, 2000·Molecular Therapy : the Journal of the American Society of Gene Therapy·M A CurranG P Nolan
Aug 10, 2000·Neoplasia : an International Journal for Oncology Research·Michael E Berens, A Giese
Oct 6, 2000·The Journal of Clinical Investigation·Z G ZhangMichael Chopp
Mar 14, 2001·Journal of Neuro-oncology·M R Machein, K H Plate
Mar 14, 2001·Journal of Neuro-oncology·I F DunnP M Black
Nov 3, 2001·Brain Research. Brain Research Reviews·S M GloorK Frei
Mar 20, 2002·Current Neurology and Neuroscience Reports·A J BolteusG J Pilkington
Mar 29, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Zheng Gang ZhangMichael Chopp
Dec 10, 2002·Acta Neuropathologica·Rupavathana MahesparanOlav Engebraaten
Feb 27, 2003·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Xiang ZhangXian-zhen Liu
Mar 15, 2003·Cancer Letters·Pierre D MouradDaniel L Silbergeld
Apr 17, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A GieseManfred Westphal
Jun 5, 2003·Nature Medicine·Napoleone FerraraJennifer LeCouter
Sep 5, 2003·Pathophysiology of Haemostasis and Thrombosis·Jay L Degen, Joseph S Palumbo
Sep 6, 2003·Methods in Molecular Medicine·Sukriti Nag
Sep 6, 2003·Methods in Molecular Medicine·Quentin R Smith
Oct 2, 2003·Expert Opinion on Biological Therapy·Carolyn A StatonClaire E Lewis
Dec 4, 2003·Biochemical Society Transactions·I D Campbell
Jan 20, 2004·Acta Neuropathologica·Stefan W SchneiderWerner Paulus
Mar 16, 2004·Cancer Treatment and Research·Katrin LamszusManfred Westphal
Mar 16, 2004·Cancer Treatment and Research·Lorenzo BelloAndreas Bikfalvi
Mar 23, 2004·Seminars in Thrombosis and Hemostasis·Marek Z WojtukiewiczJanusz Rak
Apr 20, 2004·The International Journal of Biochemistry & Cell Biology·Anita C BellailErwin G Van Meir
Apr 28, 2004·The International Journal of Biochemistry & Cell Biology·Nicole S Harhaj, David A Antonetti
Jun 23, 2004·Neurobiology of Disease·Praveen BallabhMaiken Nedergaard
Aug 4, 2004·Genes & Development·Konrad HochedlingerRudolf Jaenisch
Sep 1, 2004·Biochemical and Biophysical Research Communications·Yongjian YangDaniel M Ramos
Oct 19, 2004·Oncogene·Martin P Playford, Michael D Schaller
Jan 28, 2005·Journal of Neuro-oncology·Tim Demuth, Michael E Berens
Jan 28, 2005·Journal of Neuro-oncology·Balveen KaurErwin G Van Meir
Feb 8, 2005·The Journal of Biological Chemistry·Donald L CourterCecilia M Giachelli
Mar 2, 2005·The Lancet Oncology·John W HensonR Gilberto Gonzalez
Apr 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Florence LefrancRobert Kiss
May 3, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Nils Hansen-AlgenstaedtWolfgang Rüther
May 3, 2005·International Journal of Clinical Oncology·Takamitsu Fujimaki
May 4, 2005·Current Neurology and Neuroscience Reports·Roger StuppMonika Hegi
Jun 7, 2005·Surgical Neurology·Pierre D MouradDaniel L Silbergeld
Jun 22, 2005·Current Treatment Options in Neurology·Mark R Gilbert, Monica Loghin
Jun 22, 2005·Neoplasia : an International Journal for Oncology Research·Christopher A LipinskiJoseph C Loftus
Jun 23, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Annick DesjardinsHenry S Friedman
Jul 12, 2005·Trends in Cell Biology·Sanford J Shattil
Jul 20, 2005·Expert Review of Neurotherapeutics·L Burt Nabors, John Fiveash


Mar 13, 2012·Journal of Neuro-oncology·David A ReardonHenry S Friedman
Jan 25, 2013·Molecular Therapy. Nucleic Acids·Hanna StedtSeppo Ylä-Herttuala
Jan 6, 2012·Molecular Biology of the Cell·Sanja IvkovicSteven S Rosenfeld
Jun 8, 2012·Journal of Signal Transduction·Luigi CatacuzzenoFabio Franciolini
Jan 21, 2011·BMC Neuroscience·Jisook LeeBrian P Eliceiri
Mar 5, 2013·PloS One·Deborah HuveldtPanos Z Anastasiadis
May 14, 2014·International Journal of Oncology·Xiaosi HanL Burt Nabors
Jul 23, 2014·BioMed Research International·Yu-Fei GaoYang Jiang
Mar 22, 2007·Expert Opinion on Therapeutic Targets·Andrew S Chi, Patrick Y Wen
Dec 8, 2006·Expert Opinion on Therapeutic Targets·Jade HomsiAdil Daud
Nov 21, 2007·Expert Review of Anticancer Therapy·Andrew S ChiPatrick Y Wen
Apr 7, 2009·Expert Review of Neurotherapeutics·Jan DrappatzPatrick Y Wen
Jan 1, 2007·Expert Opinion on Drug Discovery·Sith SathornsumeteeJeremy N Rich
Feb 27, 2009·Expert Opinion on Investigational Drugs·Sith Sathornsumetee, David A Reardon
Oct 16, 2010·Cancer Letters·Manmeet S AhluwaliaCandece L Gladson
Dec 26, 2009·Free Radical Biology & Medicine·Rheal A TownerFlorea Lupu
Jun 25, 2015·Molecular Oncology·Laura J Lewis-TuffinPanos Z Anastasiadis
Nov 8, 2008·Annals of the New York Academy of Sciences·Sith Sathornsumetee, Jeremy N Rich
Apr 21, 2011·Journal of Cellular Physiology·Luigi CatacuzzenoFabio Franciolini
Jul 15, 2009·Brain Research·Jisook LeeBrian P Eliceiri
Nov 21, 2014·Journal of Neuro-oncology·Jennie W TaylorAndrew S Chi
Oct 3, 2018·International Journal of Molecular Sciences·Luigi Catacuzzeno, Fabio Franciolini
May 24, 2007·Cancer·Sith SathornsumeteeJeremy N Rich
May 14, 2009·Journal of Neuro-oncology·John de Groot, Vanessa Milano
May 20, 2016·Molecular Cancer Therapeutics·Alessia CalganiAdriano Angelucci

Related Concepts

Blood - Brain Barrier Anatomy
Brain Tumor, Recurrent
Vascular Permeability
Cerebrovascular Circulation
Immunofluorescence Assay
Mixed Gliomas
Neoplasm Invasiveness
Neoplasm Transplantation

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