Malignant brain tumors, such as glioblastoma, are characterized by extensive angiogenesis and permeability of the blood-brain barrier (BBB). The infiltration of glioma cells away from the primary tumor mass is a pathological characteristic of glial tumors. The infiltrating tumor cells represent a significant factor in tumor recurrence following surgical debulking, radiation, and chemotherapy treatments. Vascular endothelial growth factor (VEGF)-mediated vascular permeability (VP) has been associated with the progression of glioma tumor growth and infiltration into surrounding normal brain parenchyma. While VEGF induces a robust VP response in control mice (src+/+ or src+/-), the VP response is blocked in src-/- mice that demonstrate a 'leakage-resistant phenotype' in the brain. We used the Src-deficient mouse model to determine the role of Src in the maintenance of the BBB following orthotopic implantation and growth of glioma cells in the brain. Although solid tumor growth was the same in control and src-/- mice, the infiltrating component of glioma growth was reduced in src-/- mice. Characterization of the expression and localization of the extracellular matrix (ECM) protein fibrinogen was evaluated to determine the effect of...Continue Reading
Quantitative morphology of human glioblastoma multiforme microvessels: structural basis of blood-brain barrier defect
Expression of the vascular permeability factor/vascular endothelial growth factor gene in central nervous system neoplasms
Detection of brain tumor invasion and micrometastasis in vivo by expression of enhanced green fluorescent protein
A novel immunodeficient mouse model--RAG2 x common cytokine receptor gamma chain double mutants--requiring exogenous cytokine administration for human hematopoietic stem cell engraftment
Expression of vascular permeability factor in glioblastoma specimens: correlation with tumor vascular endothelial surface and peritumoral edema
Correlation of VEGF and angiopoietin expression with disruption of blood-brain barrier and angiogenesis after focal cerebral ischemia
Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling
Glioblastoma and cerebral microvascular endothelial cell migration in response to tumor-associated growth factors
Up-regulation of vascular endothelial growth factor-A by active membrane-type 1 matrix metalloproteinase through activation of Src-tyrosine kinases.
Transmission of glioblastoma multiforme following bilateral lung transplantation from an affected donor: case study and review of the literature
SRC-mediated phosphorylation of focal adhesion kinase couples actin and adhesion dynamics to survival signaling
Src-mediated tyrosine phosphorylation of caveolin-1 induces its association with membrane type 1 matrix metalloproteinase.
Src kinase activity is required for integrin alphaVbeta3-mediated activation of nuclear factor-kappaB
Contribution of gap junctional communication between tumor cells and astroglia to the invasion of the brain parenchyma by human glioblastomas
Possible future issues in the treatment of glioblastomas: special emphasis on cell migration and the resistance of migrating glioblastoma cells to apoptosis
FAK-mediated src phosphorylation of endophilin A2 inhibits endocytosis of MT1-MMP and promotes ECM degradation
Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy
Direct inhibition of myosin II effectively blocks glioma invasion in the presence of multiple motogens
EORTC 26083 phase I/II trial of dasatinib in combination with CCNU in patients with recurrent glioblastoma
Expression and Role of the Intermediate-Conductance Calcium-Activated Potassium Channel KCa3.1 in Glioblastoma
Conditional deletion of the focal adhesion kinase FAK alters remodeling of the blood-brain barrier in glioma
Pharmacologic blockade of FAK autophosphorylation decreases human glioblastoma tumor growth and synergizes with temozolomide
SAHA enhances synaptic function and plasticity in vitro but has limited brain availability in vivo and does not impact cognition
Orthotopic transplantation of v-src-expressing glioma cell lines into immunocompetent mice: establishment of a new transplantable in vivo model for malignant glioma
Effects and mechanism analysis of vascular endothelial growth factor and salvianolic acid B on 125I-low density lipoprotein permeability of the rabbit aortary endothelial cells
Regulation of angiogenesis and vascular permeability by Src family kinases: opportunities for therapeutic treatment of solid tumors
Permeability of the blood-tumor barrier is enhanced by combining vascular endothelial growth factor with papaverine
Identification of key signaling molecules involved in the activation of the swelling-activated chloride current in human glioblastoma cells
Cooperative expression of junctional adhesion molecule-C and -B supports growth and invasion of glioma
Role of KCa3.1 Channels in Modulating Ca2+ Oscillations during Glioblastoma Cell Migration and Invasion
Silencing of the tumor suppressor gene WNK2 is associated with upregulation of MMP2 and JNK in gliomas
Suppression of SRC Signaling Is Effective in Reducing Synergy between Glioblastoma and Stromal Cells
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