Reduced global myocardial perfusion reserve in DCM and HCM patients assessed by CMR-based velocity-encoded coronary sinus flow measurements and first-pass perfusion imaging

Clinical Research in Cardiology : Official Journal of the German Cardiac Society
Michael BietenbeckAli Yilmaz

Abstract

Coronary microvascular dysfunction (CMD) is an independent predictor of poor prognosis in patients suffering from dilative or hypertrophic cardiomyopathy (DCM/HCM). To assess CMD, quantitative myocardial first-pass perfusion (1P) cardiovascular magnetic resonance (CMR) can be performed. Coronary sinus flow (CSF) measurements at rest and during maximal vasodilatation are an alternative and well-validated approach for the quantification of global myocardial blood flow (MBF) in CMR. Global myocardial perfusion reserve (MPR) was used to compare both methods, 1P and CSF. This measure reflects the ratio of myocardial blood flow during maximal coronary vasodilatation over rest. 1P-MPR and CSF-MPR were calculated in 17 HCM patients, 14 DCM patients and 16 controls, who underwent a stress CMR study to rule out obstructive coronary artery disease. All patients were examined on a 1.5-T system and the study protocol comprised both, first-pass myocardial perfusion imaging (MPI) and velocity-encoded (VENC) phase-contrast imaging of CSF during rest and adenosine stress. 1P-MPR was significantly decreased only in HCM patients compared to controls (1.14 vs. 1.43, p = 0.045) whereas CSF-MPR was significantly reduced in both patient groups, HCM a...Continue Reading

References

Jun 1, 1983·The American Journal of Cardiology·D OpherkW Kübler
Jul 21, 1998·Journal of the American College of Cardiology·M A MathierM J Semigran
Mar 10, 2001·Journal of Magnetic Resonance Imaging : JMRI·J W KoskenvuoJ J Hartiala
Jun 21, 2002·The New England Journal of Medicine·Jonathan R PantingDudley J Pennell
Sep 12, 2003·The New England Journal of Medicine·Franco CecchiPaolo G Camici
Apr 25, 2008·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Paul Knaapen, Mark Lubberink
Sep 9, 2008·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Christina DoeschAndreas E May
Nov 20, 2008·Journal of Clinical Pathology·A LukJ Butany
Jun 13, 2009·JACC. Cardiovascular Imaging·Daniel C Lee, Nils P Johnson
Sep 17, 2009·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Nico MerkleVinzenz Hombach
Oct 8, 2009·Circulation. Cardiovascular Imaging·Michael Salerno, George A Beller
Jun 26, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nathan A Pack, Edward V R DiBella
Feb 23, 2013·Radiology·Otavio R Coelho-FilhoMichael Jerosch-Herold
Mar 19, 2013·Journal of the American College of Cardiology·Theodoros D KaramitsosStefan Neubauer
Dec 25, 2013·European Heart Journal·Filippo CreaCathleen Noel Bairey Merz
Sep 23, 2014·Seminars in Nuclear Medicine·Jamshid Maddahi, René R S Packard
Apr 17, 2015·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Eva SammutAmedeo Chiribiri
Sep 4, 2015·Circulation. Heart Failure·Sairia DassStefan Neubauer
Dec 16, 2016·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Joy S ShomeAmedeo Chiribiri
Apr 8, 2017·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Peter KellmanHui Xue
Aug 12, 2017·Journal of the American College of Cardiology·Shingo KatoKazuo Kimura

❮ Previous
Next ❯

Citations

Jan 7, 2020·Cardiovascular Research·Peter OngEva Prescott
Aug 8, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Wolfgang HammStefan Brunner
May 31, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Barbara Kutryb-ZajacRyszard T Smolenski
Jul 20, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Grigorios ChatzantonisAli Yilmaz
May 7, 2020·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Grigorios ChatzantonisAli Yilmaz
Jan 24, 2021·The International Journal of Cardiovascular Imaging·Johannes H RiffelFlorian Andre

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.