Reduced glucose tolerance and insulin resistance induced by steroid treatment, relative physical inactivity, and high-calorie diet impairs the incretin effect in healthy subjects

The Journal of Clinical Endocrinology and Metabolism
K B HansenF K Knop

Abstract

The loss of incretin effect in patients with type 2 diabetes mellitus may be secondary to impaired glucose homeostasis. We investigated whether reduced glucose tolerance and insulin resistance induced by steroid treatment, relative physical inactivity, and high-calorie diet in healthy young males would impair the incretin effect. The incretin effect was measured using 75 g oral glucose tolerance test (OGTT) and isoglycemic iv glucose infusion (IIGI) in 10 healthy Caucasian normal glucose-tolerant male subjects without any family history of diabetes [age 24 + or - 3 yr (mean + or - sd); body mass index 23 + or - 2 kg/m(2); glycosylated hemoglobin 5.4 + or - 0.1%] before and at the end of a 12-d period with oral administration of prednisolone (37.5 mg once daily), high-calorie diet, and relative physical inactivity. The 12-d intervention period resulted in significant increases in body weight [79 + or - 5 vs. 80 + or - 6 kg (mean + or - sd), P = 0.03] and fasting plasma glucose (5.1 + or - 0.1 vs. 5.6 + or - 0.2 mm, P = 0.016), whereas insulin sensitivity (Matsuda index 17.6 + or - 1.7 vs. 9.2 + or - 1.0, P = 0.0001) decreased. Glucose tolerance [as assessed by the 120-min plasma glucose value after OGTT (4.9 + or - 1.1 vs. 7.8 +...Continue Reading

References

Jan 1, 1986·Diabetologia·M NauckW Creutzfeldt
Aug 1, 1986·The Journal of Clinical Endocrinology and Metabolism·M A NauckW Creutzfeldt
Mar 1, 1984·Diabetologia·F G Baldissera, J J Holst
Nov 1, 1983·Diabetologia·J J HolstF Stadil
Feb 1, 1997·The Journal of Clinical Investigation·C LambillotteJ C Henquin
Oct 23, 1997·The Journal of Clinical Investigation·F DelaunayS Okret
Mar 24, 1998·Annual Review of Medicine·L J Goodyear, B B Kahn
Jun 17, 2000·Atherosclerosis·A H Lichtenstein, U S Schwab
Aug 15, 2001·The Journal of Clinical Endocrinology and Metabolism·M B Toft-NielsenJ J Holst
Dec 17, 2005·Current Opinion in Pulmonary Medicine·Peter G Gibson, Heather Powell
Feb 16, 2006·American Journal of Physiology. Endocrinology and Metabolism·Elza MuscelliEle Ferrannini
Jun 28, 2006·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Stanley B Fiel, Walter Vincken
May 15, 2007·Gastroenterology·Laurie L Baggio, Daniel J Drucker
Sep 7, 2007·Biochemical and Biophysical Research Communications·Shalea PiteauChristopher H S McIntosh
Sep 12, 2007·Diabetologia·E FerranniniUNKNOWN Relationship between Insulin Sensitivity and Cardiovascular Disease Risk (RISC) Project Investigators
Jan 28, 2010·American Journal of Physiology. Endocrinology and Metabolism·Kristine J HareFilip K Knop
Feb 4, 2010·European Journal of Endocrinology·Daniël H van RaalteMichaela Diamant

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Citations

Sep 7, 2012·Diabetes, Obesity & Metabolism·S Herzberg-SchäferA Fritsche
Jan 12, 2012·American Journal of Physiology. Endocrinology and Metabolism·Sindhu RajanLouis H Philipson
Jan 15, 2013·Journal of Nutrition and Metabolism·Guido Di DalmaziValentina Vicennati
Nov 18, 2011·The Journal of Clinical Endocrinology and Metabolism·Galina SmushkinAdrian Vella
Jan 21, 2012·The Review of Diabetic Studies : RDS·Carolyn F Deacon, Bo Ahrén
Mar 31, 2011·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Ruiying ZhaoSai-Ching Jim Yeung
Nov 21, 2013·European Journal of Endocrinology·Carla GiordanoAnnamaria Colao
Jun 2, 2012·Journal of Endocrinological Investigation·G ArnaldiM Boscaro
Mar 7, 2013·The Journal of Clinical Endocrinology and Metabolism·Lauren M SparksPatrick Schrauwen
Jul 19, 2013·Archives of Physiology and Biochemistry·Giuseppina OpintoPiero Marchetti
Mar 7, 2012·Revista da Associação Médica Brasileira·Hector Eloy Tamez PerezStephanie Lissette Proskauer Peña
Oct 14, 2011·Trends in Endocrinology and Metabolism : TEM·Gherardo MazziottiAndrea Giustina
May 5, 2012·Diabetes/metabolism Research and Reviews·Jacqueline L Beaudry, Michael C Riddell
Apr 14, 2015·Journal of Gastroenterology and Hepatology·Anders E JunkerTina Vilsbøll
Jun 11, 2015·European Journal of Endocrinology·Francesco Ferraù, Márta Korbonits
Jan 16, 2018·Acta Diabetologica·Caterina ConteNicola Napoli
Apr 22, 2018·European Journal of Endocrinology·Filip K Knop
Sep 2, 2014·Diabetology & Metabolic Syndrome·Amélio F Godoy-Matos
Jan 22, 2011·The Journal of Clinical Endocrinology and Metabolism·Jonatan I BaggerTina Vilsbøll
Oct 14, 2017·The Journal of Pharmacology and Experimental Therapeutics·Jun ZhouZhengPing Jia
Dec 19, 2015·Journal of Applied Physiology·Signe Tellerup NielsenRikke Krogh-Madsen
Nov 14, 2019·Hormones : International Journal of Endocrinology and Metabolism·Kalliopi J IoakimStavroula A Paschou
Nov 30, 2019·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Bharat K R SanapalliVeera V S R Karri
Apr 1, 2015·The Journal of Clinical Endocrinology and Metabolism·Benedikt A AulingerDavid A D'Alessio
Nov 13, 2019·Current Diabetes Reviews·Vivek Kumar Sharma, Thakur Gurjeet Singh
Oct 29, 2013·The Journal of Pharmacology and Experimental Therapeutics·Dana K SindelarDonald R Gehlert
Nov 15, 2017·Diabetes/metabolism Research and Reviews·Xiangxiang WangYongfeng Song
Mar 15, 2015·Diabetology International·Chisaki IshibashiIichiro Shimomura
Apr 2, 2017·Current Diabetes Reports·G MazziottiA Giustina
Jan 29, 2021·The Journal of Clinical Endocrinology and Metabolism·Sriram GubbiLynnette K Nieman
Apr 29, 2019·Metabolism: Clinical and Experimental·Jens Juul Holst

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