Reduced Glutathione Mediates Resistance to H2S Toxicity in Oral Streptococci

Applied and Environmental Microbiology
Xi Jia Ooi, Kai Soo Tan

Abstract

Periodontal disease is associated with changes in the composition of the oral microflora, where health-associated oral streptococci decrease while Gram-negative anaerobes predominate in disease. A key feature of periodontal disease-associated anaerobes is their ability to produce hydrogen sulfide (H2S) abundantly as a by-product of anaerobic metabolism. So far, H2S has been reported to be either cytoprotective or cytotoxic by modulating bacterial antioxidant defense systems. Although oral anaerobes produce large amounts of H2S, the potential effects of H2S on oral streptococci are currently unknown. The aim of this study was to determine the effects of H2S on the survival and biofilm formation of oral streptococci. The growth and biofilm formation of Streptococcus mitis and Streptococcus oralis were inhibited by H2S. However, H2S did not significantly affect the growth of Streptococcus gordonii or Streptococcus sanguinis. The differential susceptibility of oral streptococci to H2S was attributed to differences in the intracellular concentrations of reduced glutathione (GSH). In the absence of GSH, H2S elicited its toxicity through an iron-dependent mechanism. Collectively, our results showed that H2S exerts antimicrobial effect...Continue Reading

References

Dec 1, 1992·Oral Microbiology and Immunology·S Persson
Jun 1, 1990·Oral Microbiology and Immunology·R ClaessonJ Carlsson
Jul 1, 1973·Journal of Periodontology·A Horowitz, L E Folke
Apr 1, 1996·Journal of Bacteriology·J A ChesneyJ R Mahoney
Jan 22, 1998·Applied and Environmental Microbiology·J C DunningR E Marquis
Apr 16, 1999·Oral Microbiology and Immunology·C E Caldwell, R E Marquis
Aug 9, 2001·Journal of Clinical Periodontology·M Morita, H L Wang
Mar 13, 2002·Journal of Bacteriology·Vinayak KapatralRoss Overbeek
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hilde SteinmoenLeiv Sigve Håvarstein
Apr 19, 2003·The Journal of Biological Chemistry·Christopher Horst LilligArne Holmgren
Jun 1, 1953·Journal of General Microbiology·P H CLARKE
Oct 9, 2003·Applied and Environmental Microbiology·Yin LiDouwe Molenaar
Feb 6, 2004·Journal of Clinical Periodontology·G TorresyapS S Socransky
Aug 6, 2005·Journal of Clinical Microbiology·James R UhlFranklin R Cockerill
Jun 15, 2006·Antioxidants & Redox Signaling·Lluis MasipGeorge Georgiou
Dec 6, 2006·Drug Metabolism Reviews·Don H TruongPeter J O'Brien
Feb 6, 2007·Journal of Bacteriology·Ping XuGregory A Buck
Oct 13, 2009·Antonie van Leeuwenhoek·Sean M Caffrey, Gerrit Voordouw
Jun 2, 2010·Nature Reviews. Microbiology·Paul E KolenbranderNicholas S Jakubovics
Nov 19, 2011·Science·Konstantin ShatalinEvgeny Nudler
Mar 24, 2012·Future Microbiology·Leroy G HenryHansel M Fletcher
Aug 1, 2012·Oxidative Medicine and Cellular Longevity·Lin Zhu, Jens Kreth
Sep 1, 2012·Journal of Dental Research·P I EkeR J Genco
Oct 19, 2012·Biochimica Et Biophysica Acta·Robert C Fahey
Jan 1, 2012·Journal of Functional Biomaterials·Ken WelchMaria Strømme

❮ Previous
Next ❯

Citations

Mar 2, 2018·The Journal of Microbiology·Liu-Hui FuHua Zhang
Dec 7, 2018·Applied and Environmental Microbiology·Eman RamadanHamza El Dorry
Aug 3, 2017·Digestive Diseases and Sciences·Larry L BartonHenry C Lin
Jul 24, 2020·The Journal of Biological Chemistry·Brenna J C Walsh, David P Giedroc
Aug 28, 2020·Frontiers in Microbiology·Say Yong NgWilfried Moreira
Aug 12, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Nahzli DilekCsaba Szabo
Nov 11, 2021·Nucleic Acids Research·Joseph N FakhouryDavid P Giedroc

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Anthrax

Anthrax toxin, comprising protective antigen, lethal factor, and oedema factor, is the major virulence factor of Bacillus anthracis, an agent that causes high mortality in humans and animals. Here is the latest research on Anthrax.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Anthrax Vaccines

Three different types of anthrax vaccines are available; a live-attenuated, an alum-precipitated cell-free filtrate and a protein recombinant vaccine. The effectiveness between the three is uncertain, but the live-attenuated have shown to reduce the risk of anthrax with low adverse events. Here is the latest research on anthrax vaccines.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Biofilms

Biofilms are adherent bacterial communities embedded in a polymer matrix and can cause persistent human infections that are highly resistant to antibiotics. Discover the latest research on Biofilms here.

Anthrax Vaccines (ASM)

Three different types of anthrax vaccines are available; a live-attenuated, an alum-precipitated cell-free filtrate and a protein recombinant vaccine. The effectiveness between the three is uncertain, but the live-attenuated have shown to reduce the risk of anthrax with low adverse events. Here is the latest research on anthrax vaccines.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.