Reduced gray matter in the anterior cingulate gyrus in familial schizophrenia: a preliminary report.

Schizophrenia Research
Gregory CostainAnne S Bassett

Abstract

Few brain imaging studies of schizophrenia involve samples with enhanced genetic homogeneity. We compared MRI volumetric data between individuals with 1q21-q23 linked familial schizophrenia associated with NOS1AP and their first and second degree unaffected relatives. We found significant gray matter reductions in the anterior cingulate gyrus in both affected individuals and their unaffected first degree relatives when compared with their unaffected second degree relatives. These results suggest that the changes are primarily due to genetic risk and not illness effects, and may represent an intermediate phenotype.

References

Jan 1, 1991·Biological Psychiatry·T L JerniganJ R Hesselink
Dec 1, 1993·Schizophrenia Research·A S BassettW G Honer
Dec 7, 2005·The American Journal of Psychiatry·Robyn HoneaClare E Mackay
Jan 31, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Janice A HustedAnne S Bassett
Mar 4, 2009·The American Journal of Psychiatry·Naomi S WrattenLinda M Brzustowicz

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