Reduced heart rate variability in a treatment-seeking early psychosis sample

Psychiatry Research
Cristina Cacciotti-SaijaAdam J Guastella

Abstract

Reduced cardiac autonomic function is associated with increased risk of cardiovascular disease (CVD), with heart rate variability (HRV) providing an accessible index of cardiac autonomic function. HRV may provide a candidate physiological mechanism linking reduced cardiac autonomic function to increased risk for CVD in schizophrenia illness. This study examines whether HRV is also reduced in a community sample of treatment-seeking participants experiencing early psychosis (n = 48) compared to healthy volunteers (n = 48) and social anxiety control groups (n = 48) matched by gender and age. HRV was assessed during a five-minute interbeat interval recording at rest. Participants also completed self-report psychiatric symptom measures. Early psychosis participants showed significant reductions in HRV compared to social anxiety and healthy control groups. Reductions in HRV were also observed in early psychosis participants taking anticholinergic medications compared to both control groups taking cardio-benign medications or who were non-medicated. Lastly, whether or not early psychosis participants were taking anticholinergic medications was not associated with reductions in HRV. Findings provide preliminary evidence that early psyc...Continue Reading

Citations

Apr 12, 2019·Autism Research : Official Journal of the International Society for Autism Research·Rinku ThapaAdam J Guastella
Nov 27, 2019·Issues in Mental Health Nursing·Kayla HerbellElizabeth Williams
Nov 24, 2020·Autism Research : Official Journal of the International Society for Autism Research·Rinku ThapaAdam J Guastella
Feb 20, 2021·Journal of Clinical Psychopharmacology·Johan BengtssonRobert Bodén
Apr 28, 2021·NPJ Schizophrenia·Nicolette StogiosSri Mahavir Agarwal

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