Reduced hemispheric asymmetry of brain anatomical networks in attention deficit hyperactivity disorder

Brain Imaging and Behavior
Dandan LiBin Wang

Abstract

Despite many studies reporting a variety of alterations in brain networks in patients with attention deficit hyperactivity disorder (ADHD), alterations in hemispheric anatomical networks are still unclear. In this study, we investigated topology alterations in hemispheric white matter in patients with ADHD and the relationship between these alterations and clinical features of the illness. Weighted hemispheric brain anatomical networks were first constructed for each of 40 right-handed patients with ADHD and 53 matched normal controls. Then, graph theoretical approaches were utilized to compute hemispheric topological properties. The small-world property was preserved in the hemispheric network. Furthermore, a significant group-by-hemisphere interaction was revealed in global efficiency, local efficiency and characteristic path length, attributed to the significantly reduced hemispheric asymmetry of global and local integration in patients with ADHD compared with normal controls. Specifically, reduced asymmetric regional efficiency was found in three regions. Finally, we found that the abnormal asymmetry of hemispheric brain anatomical network topology and regional efficiency were both associated with clinical features (the Adu...Continue Reading

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Citations

Jul 4, 2019·Journal of Attention Disorders·Hongliang Zou, Jian Yang
Dec 31, 2019·Journal of Attention Disorders·Dandan LiBing Wang
Jul 3, 2020·Brain and Behavior·Qian RanPatrick Dupont
May 28, 2020·Brain Connectivity·Subaramya SrivishaganNagulan Ratnarajah
Mar 23, 2021·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Merel C PostemaClyde Francks
May 25, 2021·Psychiatry Research. Neuroimaging·Jennifer E Siegel-RamsayMaria R Dauvermann
Feb 9, 2020·Psychiatry Research·Zhao-Min WuYu-Feng Wang

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Methods Mentioned

BETA
SMA

Software Mentioned

BrainNet Viewer
GRETNA
SPSS
PANDA
MATLAB
MPRAGE
openfMRI

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