PMID: 15331546Aug 28, 2004Paper

Reduced hepatic insulin extraction in response to gastric inhibitory polypeptide compensates for reduced insulin secretion in normal-weight and normal glucose tolerant first-degree relatives of type 2 diabetic patients

Diabetes
Natalia N RudovichAndreas F H Pfeiffer

Abstract

Our objective was to study whether young first-degree relatives of patients with type 2 diabetes (FDRs) have altered insulin secretion and insulin clearance in response to gastric inhibitory polypeptide (GIP) in combination with glucose and arginine. A hyperglycemic clamp (11.1 mmol/l for 115 min), followed by addition of GIP (2 pmol. kg(-1). min(-1), 60-115 min) and an arginine bolus and infusion (10 mg. kg(-1). min(-1), 90-115 min), was conducted on 14 healthy volunteers and 13 FDRs. Both groups had normal glucose tolerance. FDRs were more insulin resistant (HOMA(IR)) under basal conditions (P = 0.003). FDRs demonstrated significant global impairment in insulin secretion capacity, which was not specific for one of the secretagogues. Insulin clearance was significantly reduced in the group of FDRs under basal conditions and in response to GIP, but there was no general defect in insulin clearance in response to glucose and arginine. The HOMA(IR) correlated negatively (P < 0.01) with insulin clearance under basal conditions (r = -0.96) and under GIP infusion (r = -0.56). We propose that impairment in insulin secretion capacity and decreased insulin sensitivity is compensated for several mechanisms, one of which includes a GIP-de...Continue Reading

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Citations

Oct 8, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Natalia RudovichAndreas F H Pfeiffer
Sep 21, 2013·The Journal of Clinical Investigation·Motoyuki TamakiHirotaka Watada
Aug 31, 2006·Expert Opinion on Emerging Drugs·Brian D GreenClifford J Bailey
Sep 15, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·Nigel Irwin, Peter R Flatt
Dec 7, 2007·Best Practice & Research. Clinical Endocrinology & Metabolism·Brian D Green, Peter R Flatt
Apr 29, 2005·Diabetes/metabolism Research and Reviews
Apr 30, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fernando BrilKenneth Cusi
May 7, 2015·Cell Cycle·Olga PivovarovaNatalia Rudovich
Sep 13, 2013·Diabetes Care·Olga PivovarovaNatalia Rudovich
Jun 21, 2016·Annals of Medicine·Olga PivovarovaNatalia Rudovich
Dec 13, 2006·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Brian D GreenClifford J Bailey
Mar 30, 2017·Journal of Asian Natural Products Research·Anand-Krishna SinghHeera Ram
Jan 20, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrea TuraBo Ahrén
Nov 22, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrea TuraBo Ahrén
Jan 1, 2009·Diabetes/metabolism Research and Reviews·Olga PivovarovaNatalia Rudovich
Jul 26, 2019·The Proceedings of the Nutrition Society·Alan Fappi, Bettina Mittendorfer
Feb 14, 2020·The Journal of Clinical Endocrinology and Metabolism·Andin FosamRanganath Muniyappa
Jun 4, 2020·Diabetes, Obesity & Metabolism·Meera LadwaLouise M Goff
Jul 5, 2007·American Journal of Physiology. Endocrinology and Metabolism·Juris J MeierMichael A Nauck
May 2, 2020·BMJ Open Diabetes Research & Care·Tsuyoshi OkuraKazuhiro Yamamoto
Sep 25, 2016·The Journal of Biological Chemistry·Sadeesh K RamakrishnanSonia M Najjar
Mar 7, 2021·International Journal of Molecular Sciences·Malcolm A LeissringGermán Perdomo
Jul 19, 2021·The American Journal of the Medical Sciences·Xiu-Ping BaiXing Li

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