PMID: 7145Jun 1, 1976

Reduced high-energy phosphate levels in rat hearts. I. Effects of alloxan diabetes

The American Journal of Physiology
T B AllisonJ C Shipp

Abstract

Significant alterations in heart carbohydrate and lipid metabolism are present 48 h after intravenous injection of alloxan (60 mg/kg) in rats. It has been suggested that uncoupling of oxidative phosphorylation occurs in the alloxanized rat heart in vivo, whereas normal oxidative metabolism has been demonstrated in alloxan-diabetic rat hearts perfused in vitro under conditions of adequate oxygen delivery. We examined the hypothesis that high-energy phosphate metabolism might be adversely affected in the alloxan-diabetic rat heart in vivo. Phosphocreatine and ATP were reduced by 58 and 45%, respectively (P is less than 0.001). Also, oxygen-dissociation curves were shifted to the left by 4 mmHg, and the rate of oxygen release from blood was reduced by 21% (P is less than 0.01). Insulin administration normalized heart high-energy phosphate compounds. ATP production was accelerated in diabetic hearts perfused in vitro with a well-oxygenated buffer. These studies support the hypothesis that oxidative ATP production in the alloxan-diabetic rat heart is reduced and suggest that decreased oxygen delivery may have a regulatory role in the oxidative metabolism of the diabetic rat heart.

Citations

Sep 28, 2002·Journal of Cardiovascular Pharmacology·Tomoko NawataToshiie Sakata
Feb 1, 1994·Cardiovascular Drugs and Therapy·F S Fein, E H Sonnenblick
Dec 1, 1980·Circulation Research·S PenpargkulJ Scheuer
May 31, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·R VettorE Nisoli
Nov 1, 2003·Japanese Heart Journal·Chiharu NodaTohru Izumi
Jul 1, 1983·The American Journal of Physiology·V ChenJ J Spitzer
Oct 1, 1989·The American Journal of Physiology·B K PopovichW H Dillmann

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