Reduced Histone Expression or a Defect in Chromatin Assembly Induces Respiration

Molecular and Cellular Biology
Luciano GaldieriAles Vancura

Abstract

Regulation of mitochondrial biogenesis and respiration is a complex process that involves several signaling pathways and transcription factors as well as communication between the nuclear and mitochondrial genomes. Here we show that decreased expression of histones or a defect in nucleosome assembly in the yeast Saccharomyces cerevisiae results in increased mitochondrial DNA (mtDNA) copy numbers, oxygen consumption, ATP synthesis, and expression of genes encoding enzymes of the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS). The metabolic shift from fermentation to respiration induced by altered chromatin structure is associated with the induction of the retrograde (RTG) pathway and requires the activity of the Hap2/3/4/5p complex as well as the transport and metabolism of pyruvate in mitochondria. Together, our data indicate that altered chromatin structure relieves glucose repression of mitochondrial respiration by inducing transcription of the TCA cycle and OXPHOS genes carried by both nuclear and mitochondrial DNA.

References

Jan 1, 1991·Methods in Enzymology·F Sherman
Aug 1, 1966·Journal of General Microbiology·R H De Deken
Jun 10, 1998·Microbiology and Molecular Biology Reviews : MMBR·J M Gancedo
Feb 24, 2001·Cellular and Molecular Life Sciences : CMLS·L Zhang, A Hach
Mar 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Alexander EgnerStefan W Hell
Mar 22, 2002·Molecular Biology of the Cell·Kai Stefan DimmerBenedikt Westermann
Nov 5, 2003·The Journal of Biological Chemistry·Steffen OhlmeierUlrich Bergmann
Sep 3, 2004·Nature·Christopher T HarbisonRichard A Young
Sep 29, 2004·The Journal of Biological Chemistry·Melissa W Adkins, Jessica K Tyler
Dec 4, 2004·Biochimica Et Biophysica Acta·Carlos T MoraesAntoni Barrientos
Mar 9, 2006·BMC Bioinformatics·Kenzie D MacIsaacErnest Fraenkel
Mar 10, 2006·Microbiology and Molecular Biology Reviews : MMBR·George M Santangelo
Jun 15, 2006·Annual Review of Genetics·Zhengchang Liu, Ronald A Butow
Jul 25, 2006·Current Biology : CB·Heidi M McBrideSylwia Wasiak
Apr 7, 2007·Current Biology : CB·David C Bouck, Kerry Bloom
May 18, 2007·The Journal of Biological Chemistry·Jeffrey S BlackwellLucy F Pemberton
Feb 29, 2008·Annual Review of Genetics·Shadia ZamanJames R Broach
Feb 20, 2009·Molecular Systems Biology·Shadia ZamanJames R Broach
May 23, 2009·Science·Kathryn E WellenCraig B Thompson
Jul 7, 2009·Annual Review of Physiology·M Benjamin Hock, Anastasia Kralli

❮ Previous
Next ❯

Citations

Dec 7, 2016·Nature Structural & Molecular Biology·Jane Mellor
Apr 6, 2018·Biochemistry. Biokhimii︠a︡·T A Trendeleva, R A Zvyagilskaya
Dec 8, 2017·Oncotarget·Qianyun MeiShanshan Li
Dec 15, 2018·The European Journal of Neuroscience·Helen C Causton
Mar 29, 2020·Molecular Metabolism·Meike Wiese, Andrew J Bannister
Apr 17, 2021·Biochimica Et Biophysica Acta. Molecular Cell Research·Madhura BhagwatAles Vancura

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.