Reduced hyaluronan cross-linking induces breast cancer malignancy in a CAF-dependent manner.

Cell Death & Disease
Guoliang ZhangFeng Gao

Abstract

Hyaluronan (HA) cross-linking is a conformational state of HA, a covalent complex between HA and heavy chains (HCs) from inter-α-trypsin inhibitor (I-α-I) mediated by tumor necrosis factor-induced protein 6 (TSG6). Cross-linked HA has been identified as a protective factor in physiological and inflammatory conditions. However, the state of HA cross-linking in tumor microenvironment has not been fully elucidated. As a major constituent of the extracellular matrix (ECM), HA is mainly synthesized by cancer-associated fibroblasts (CAFs). Our study aimed to clarify the role of HA cross-linking in breast cancer malignancy. Compared to normal mammary gland tissues, cross-linked HA levels were significantly decreased in breast cancer and associated with tumor malignancy. When NFbs were activated into CAFs, the levels of cross-linked HA and TSG6 were both suppressed. Through upregulating TSG6, CAFs restored the high level of cross-linked HA and significantly inhibited breast cancer malignancy, whereas NFbs promoted the malignancy when the cross-linked HA level was reduced. Furthermore, the inhibitory role of HA cross-linking in tumor malignancy was directly verified using the synthesized HA-HC complex. Collectively, our study found that...Continue Reading

References

Sep 5, 2003·The Journal of Biological Chemistry·Alana K MajorsScott A Strong
Dec 6, 2003·Journal of Cell Science·Christina FieberJonathan P Sleeman
Oct 11, 2005·Trends in Immunology·Anthony J Day, Carol A de la Motte
Jan 13, 2006·The Journal of Biological Chemistry·Kazuki N SugaharaMasayuki Miyasaka
Mar 27, 2007·Matrix Biology : Journal of the International Society for Matrix Biology·Claudia BaierJoachim Kappler
Nov 30, 2007·The Journal of Pathology·A BergamaschiA-L Børresen-Dale
Nov 17, 2009·Matrix Biology : Journal of the International Society for Matrix Biology·Feng GaoGuo Wei
Nov 26, 2009·Cell·Kandice R LeventalValerie M Weaver
Feb 22, 2012·Breast Cancer Research and Treatment·Sebastian F SchoppmannPeter Birner
Nov 21, 2012·The Journal of Biological Chemistry·Mark E LauerAnthony Calabro
Sep 6, 2013·The Journal of Biological Chemistry·Natalia S BaranovaRalf P Richter
Jan 10, 2014·The Journal of Biological Chemistry·Mark E LauerRaed A Dweik
Mar 22, 2014·Frontiers in Immunology·Aaron C Petrey, Carol A de la Motte
Nov 10, 2014·EMBO Reports·Michael W PickupValerie M Weaver
Jan 1, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Man WuFeng Gao
Jun 25, 2015·Frontiers in Immunology·Kathryn L SchwertfegerJames B McCarthy
Aug 24, 2016·Nature Reviews. Cancer·Raghu Kalluri
Nov 26, 2016·Journal of Experimental & Clinical Cancer Research : CR·Ziwen ZhangHongbing Jiang
Dec 23, 2016·Genes & Development·Anna BrichkinaDmitry V Bulavin
Jan 19, 2018·International Journal of Molecular Sciences·Eva Nagyova
Jun 2, 2018·Respiratory Research·Kevin NiIrina Petrache
Jun 6, 2018·Frontiers in Cell and Developmental Biology·James B McCarthyEva A Turley
Sep 4, 2018·Developmental Cell·Aravind SivakumarNatasza A Kurpios
Feb 7, 2019·The FEBS Journal·Anastasia G TavianatouNikos K Karamanos

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Citations

Oct 26, 2021·Advanced Healthcare Materials·Ana M CarvalhoIva Pashkuleva

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