Reduced immobilizing properties of isoflurane and nitrous oxide in mutant mice lacking the N-methyl-D-aspartate receptor GluR(epsilon)1 subunit are caused by the secondary effects of gene knockout

Anesthesia and Analgesia
Andrey B PetrenkoHiroshi Baba

Abstract

Until recently, the N-methyl-D-aspartate (NMDA) receptor was considered to possibly mediate the immobility produced by inhaled anesthetics such as isoflurane and nitrous oxide. However, new evidence suggests that the role of this receptor in abolition of the movement response may be less important than previously thought. To provide further evidence supporting or challenging this view, we examined the anesthetic potencies of isoflurane and nitrous oxide in genetically modified animals with established NMDA receptor dysfunction caused by GluRepsilon1 subunit knockout. The immobilizing properties of inhaled anesthetics in mice quantitated by the minimum alveolar anesthetic concentration (MAC) were evaluated using the classic tail clamp method. Compared with wild-type controls, NMDA receptor GluRepsilon1 subunit knockout mice displayed larger isoflurane MAC values indicating a resistance to the immobilizing action of isoflurane. Knockout mice were previously shown to have enhanced monoaminergic tone as a result of genetic manipulation, and this increase in MAC could be abolished in our experiments by pretreatment with the serotonin 5-hydroxytryptamine type 2A receptor antagonist ketanserin or with the dopamine D2 receptor antagoni...Continue Reading

References

Jan 1, 1996·Behavioural Brain Research·M A Geyer
Dec 20, 1993·Annals of the New York Academy of Sciences·M WatanabeM Mishina
May 28, 2003·Neuroscience Research·Andrei B PetrenkoKenji Sakimura
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Aug 21, 2008·Anesthesia and Analgesia·Edmond I EgerJames M Sonner

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Citations

Dec 18, 2013·European Journal of Pharmacology·Andrey B PetrenkoHiroshi Baba
Dec 24, 2015·Frontiers in Psychiatry·Charles F ZorumskiCharles R Conway
Jan 24, 2018·Journal of Clinical Psychopharmacology·Peter NageleCharles Conway
Nov 5, 2014·The Journal of Pharmacology and Experimental Therapeutics·Kellianne J Richardson, Keith L Shelton
Apr 26, 2011·Respiratory Physiology & Neurobiology·Luc J Teppema, Santhosh Baby

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