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Reduced immunopathology and mortality despite tissue persistence in a Mycobacterium tuberculosis mutant lacking alternative sigma factor, SigH

Proceedings of the National Academy of Sciences of the United States of America

Jun 13, 2002

Deepak KaushalWilliam R Bishai

Abstract

The pathogenesis of tuberculosis involves multiple phases and is believed to involve both a carefully deployed series of adaptive bacterial virulence factors and inappropriate host immune responses that lead to tissue damage. A defined Mycobacterium tuberculosis mutant strain lacking th...read more

Mentioned in this Paper

Flow Cytometry
Bacterial Proteins
Systemic Inflammatory Response Syndrome
Pathogenicity
Lung
Tuberculosis
Spleen
Gene Deletion
Near-Death Experience
Lung Diseases
82
Paper Details
References
  • References37
  • Citations128
1234
  • References37
  • Citations128
12345...

Reduced immunopathology and mortality despite tissue persistence in a Mycobacterium tuberculosis mutant lacking alternative sigma factor, SigH

Proceedings of the National Academy of Sciences of the United States of America

Jun 13, 2002

Deepak KaushalWilliam R Bishai

PMID: 12060776

DOI: 10.1073/pnas.102055799

Abstract

The pathogenesis of tuberculosis involves multiple phases and is believed to involve both a carefully deployed series of adaptive bacterial virulence factors and inappropriate host immune responses that lead to tissue damage. A defined Mycobacterium tuberculosis mutant strain lacking th...read more

Mentioned in this Paper

Flow Cytometry
Bacterial Proteins
Systemic Inflammatory Response Syndrome
Pathogenicity
Lung
Tuberculosis
Spleen
Gene Deletion
Near-Death Experience
Lung Diseases
82

Related Papers

Paper Details
References
  • References37
  • Citations128
1234
  • References37
  • Citations128
12345...
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